Citation: Di ZHANG, Tianxiang XIE, Xu HE, Wanyu WEI, Qi FAN, Jie QIAO, Gang JIN, Ningbo LI. Construction and antitumor activity of pH/GSH dual-responsive magnetic nanodrug[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(4): 786-796. doi: 10.11862/CJIC.20240329 shu

Construction and antitumor activity of pH/GSH dual-responsive magnetic nanodrug

Di ZHANG ¹ ,
Tianxiang XIE ² ,
Xu HE ¹ ,
Wanyu WEI ¹ ,
Qi FAN ¹ ,
Jie QIAO ¹ ,
Gang JIN ^3,, ,
Ningbo LI ^1,,

1.
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
2.
School of Stomatology, Shanxi Medical University, Taiyuan 030001, China
3.
Department of Radiation Oncology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China

Corresponding author: Gang JIN, jingang2018@sina.com Ningbo LI, ningboli@sxmu.edu.cn
Received Date: 9 September 2024
Revised Date: 5 January 2025

Figures(9)

Herein, a mesoporous magnetic nanocarrier containing disulfide bonds (NH₂-SMNPs) was developed to improve the efficacy of tumor treatment and reduce side effects. After loading the carrier with doxorubicin (DOX), a nontoxic pullulan oxide was used as a gating material to form the oSMNPs/DOX nanodrug. This nanodrug exhibited uniform dispersion, good drug-loading capacity, and high saturation magnetization, enabling pH/glutathione (GSH) dual-responsive drug release in the tumor microenvironment, with a release rate as high as 81.53%. Furthermore, this nanodrug demonstrated good biocompatibility, effective capability to kill cancer cells, and competent cellular uptake ability.
- magnetic materials,
- mesoporous silica,
- pH/GSH dual-responsive
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