Citation: Jing WU, Puzhen HUI, Huilin ZHENG, Pingchuan YUAN, Chunfei WANG, Hui WANG, Xiaoxia GU. Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(12): 2422-2428. doi: 10.11862/CJIC.20240278 shu

Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand

Jing WU ¹ ,
Puzhen HUI ¹ ,
Huilin ZHENG ¹ ,
Pingchuan YUAN ¹ ,
Chunfei WANG ¹ ,
Hui WANG ^{1, 2,,} ,
Xiaoxia GU ^{1, 2,,}

1.
College of Pharmacy, Wannan Medical College, Wuhu, Anhui 241002, China
2.
Institute of Synthesis and Application of Medical Materials, Wannan Medical College, Wuhu, Anhui 241002, China

Corresponding author: Hui WANG, wanghias@126.com Xiaoxia GU, guxiaoxia@wnmc.edu.cn
Received Date: 23 July 2024
Revised Date: 30 September 2024

Figures(4)

To study the synthesis and antitumor activities of the transition metal complexes incorporating a novel naphthol-aldehyde Schiff base ligand, three transition metal complexes [Cu(L)₂(DMF)₂] (1), [Ni(L)₂(DMF)₂] (2), and [Zn(L)₂] (3) were synthesized using a Schiff base of N-[(2-hydroxy-1-naphthalenyl)methylene]-[(1H-indol-3-yl)ethyl] imine (HL) by liquid diffusion method. The complexes 1-3 were characterized by IR analysis, elemental analysis, and single-crystal X-ray diffraction. Moreover, their antitumor activities in vitro were screened through three human cancer cell lines (MGC-803, A549, MDA-MB-231) by the MTT assay. It revealed that complexes 1-3 showed high antitumor activities. Complex 1 showed much higher antitumor activities than complexes 2 and 3, and even than cisplatin. Among them, complex 1 had the highest inhibitory effects on tumor cells with its IC₅₀ value (half-inhibitory concentration) being (4.8±0.2) μmol·L^-1 against MGC-803 cells. These demonstrated a potential anti-cancer candidate for complex 1, which induced MGC-803 cancer cells' late apoptosis by flow cytometry. Subsequently, the cell scraper experiment showed that the killing effect of MGC-803 cells was enhanced with the increase in the concentration of complex 1.
- naphthol-aldehyde Schiff base,
- transition metal complex,
- synthesis,
- crystal structure,
- antitumor activity
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