Citation: Jinghan ZHANG, Guanying CHEN. Progress in the application of rare-earth-doped upconversion nanoprobes in biological detection[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(12): 2335-2355. doi: 10.11862/CJIC.20240249 shu

Progress in the application of rare-earth-doped upconversion nanoprobes in biological detection

Jinghan ZHANG ,
Guanying CHEN ^,

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China

Corresponding author: Guanying CHEN, chenguanying@hit.edu.cn
Received Date: 2 July 2024
Revised Date: 29 October 2024

Figures(14)

The responsive optical sensor demonstrates broad potential for specific detection and micro-quantitative analysis. Rare-earth-doped upconversion nanoparticle (UCNP), owing to their unique fluorescence properties, large anti-Stokes shift, good biocompatibility, and resistance to autofluorescence interference, can serve as emerging optical labels for achieving high-sensitivity biological detection at deeper tissue levels. This review focuses on the prospects and key applications of UCNP-based fluorescent nanoprobes in the field of biological detection, including specific detection of ions, reactive oxygen species, gases, and biomolecules. Additionally, this review discusses the sensing mechanisms of upconversion detection and the design principles of nanoprobes, evaluates the future challenges of upconversion nanoprobes in basic research and clinical applications, and aims to provide theoretical support and experimental guidance for the wide application of UCNP in biological detection and clinical diagnosis.
- rare-earth-doped upconversion nanoparticle,
- biological detection,
- responsive fluorescent nanoprobe,
- specific detection
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