Citation: Yongjie ZHANG, Bintong HUANG, Yueming ZHAI. Research progress of formation mechanism and characterization techniques of protein corona on the surface of nanoparticles[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(12): 2318-2334. doi: 10.11862/CJIC.20240247 shu

Research progress of formation mechanism and characterization techniques of protein corona on the surface of nanoparticles

Yongjie ZHANG ¹ ,
Bintong HUANG ^{1, 2,,} ,
Yueming ZHAI ^1,,

1.
The Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, China
2.
School of Physics and Technology, Wuhan University, Wuhan 430072, China

Corresponding author: Bintong HUANG, bthuang@whu.edu.cn Yueming ZHAI, yueming@whu.edu.cn
Received Date: 30 June 2024
Revised Date: 23 October 2024

Figures(6)

In biological fluids, proteins bind to the surface of nanoparticles to form a coating named the protein corona, which can dramatically change their physicochemical properties and affect interactions with living systems. Understanding the formation mechanism and dynamic changes of protein corona can help optimize the design of nanoparticles, improve the targeting and effectiveness of nanomedicines, and reduce side effects. In this review, we first reviewed the progress of protein corona and highlighted the properties of protein corona, the factors influencing their formation, and the analytical techniques for probing the protein corona. Finally, we share our perspective on the challenges and opportunities of protein corona in characterization methods and controlling their formation and composition. This review will contribute to understanding protein corona for the development and application of nanomedicine and biotechnology.
- nanoparticle,
- nano-biological interaction,
- protein corona,
- nano-inorganic-biological interface,
- characterization method
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