Citation: Zhuoya WANG, Le HE, Zhiquan LIN, Yingxi WANG, Ling LI. Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(12): 2445-2454. doi: 10.11862/CJIC.20240194 shu

Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide

Key Laboratory of Organic Functional Molecules Synthesis and Application, Ministry of Education, Hubei University, Wuhan 430062, China

Corresponding author: Ling LI, lingli@hubu.edu.cn
Received Date: 25 May 2024
Revised Date: 20 October 2024

Figures(6)

A multifunctional nanomaterial CuO₂/PB with H₂O₂ self-supply and photothermal-enhanced enzyme-like activity was obtained by introducing CuO₂ into Prussian blue (PB). The simulated tumor microenvironment (TME) can produce H₂O₂ and consume glutathione (GSH), further enhancing the generation of ·OH and the consumption of GSH with near-infrared light irradiation. In addition, mouse experiments have shown that CuO₂/PB can be used for T₂ -magnetic resonance imagingguided tumor therapy. In the 14 d treatment cycle, combined with near-infrared light irradiation, it had a significant inhibitory effect on tumors, achieving photothermal therapy combined with H₂O₂ self-supply catalytic therapy, which provides a new idea for improving the efficiency of catalytic treatment.
- nanoparticle,
- Prussian blue,
- catalytic therapy,
- photothermal performance
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