Citation: Jinlong YAN, Weina WU, Yuan WANG. A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154 shu

A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application

Jinlong YAN ¹ ,
Weina WU ^2,, ,
Yuan WANG ²

1.
College of Science and Technology, Jiaozuo Normal College, Jiaozuo, Henan 454001, China
2.
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Coal Green Conversion, Henan Polytechnic University, Jiaozuo, Henan 454000, China

Corresponding author: Weina WU, wuwn08@hpu.edu.cn
Received Date: 4 May 2024
Revised Date: 1 July 2024

Figures(7)

A simple Schiff base probe, namely 2-(((E)-(3H-benzo[f]chromen-2-yl)methylene)amino)-3-aminomaleonitrile (1), was prepared by the condensation reaction, which was characterized through ¹H NMR, ¹³C NMR, ESI-MS, and single crystal X-ray diffraction. The fluorescence experiments indicated that probe 1 was non-emissive, while hypochlorite (ClO^-) could induce a strong emission of the probe at 530 nm. The response of probe 1 toward ClO^- was highly sensitive and finished within a few seconds. The ClO^--promoted decomposition of probe 1 was suggested by spectral and theoretical methods. Furthermore, the probe was applied to imaging exogenous and endogenous ClO^- in living cells, zebrafish, and Arabidopsis thaliana.
- benzo[f]chromene,
- biological imaging,
- fluorescent probe,
- hypochlorite,
- Schiff base
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