Citation: Maitri Bhattacharjee, Rekha Boruah Smriti, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Shubhamoy Chowdhury, Debasish Maiti, Tamanna Akhtar. Synthesis, structural characterization, bio-activity, and density functional theory calculation on Cu(Ⅱ) complexes with hydrazone-based Schiff base ligands[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(7): 1409-1422. doi: 10.11862/CJIC.20240007 shu

Synthesis, structural characterization, bio-activity, and density functional theory calculation on Cu(Ⅱ) complexes with hydrazone-based Schiff base ligands

1.
Department of Chemistry, Tripura University, Suryamaninagar-799022, Tripura, India
2.
Institute of General and Ecological Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Łódz, Poland
3.
Department of Chemistry, University of Gourbanga, Mokdumpur, Malda, West Bengal-732103, India
4.
Department of Human Physiology, Tripura University, Suryamaninagar-799022, Tripura, India

Corresponding author: R. N. Dutta Purkayastha, rndp09@gmail.com; rndp@tripurauniv.ac.in
Received Date: 4 January 2024
Revised Date: 18 April 2024

Figures(8)

Three new copper(Ⅱ) complexes 1-3 of Schiff base ligands HL¹ (2-hydroxybenzaldehyde2-(2-oxo-1, 2-diphenylethylidene)hydrazone), HL² (4-hydroxybenzaldehyde2-(2-oxo-1, 2-diphenylethylidene)hydrazone) and L³ (2-methoxybenzaldehyde2-(2-oxo-1, 2-diphenylethylidene)hydrazone) were synthesized from methanolic medium. The complexes were characterized by elemental analyses, spectroscopic methods, magnetic susceptibility measurements, and density functional theory (DFT) studies. The synthesized ligands were characterized structurally by single-crystal X-ray diffraction studies. The optimized structure of the complexes was ascertained by DFT studies. The DNA binding ability of the complexes with calf thymus DNA (CT-DNA) was studied by UV-Vis absorption and fluorescence emission spectral studies. Absorption spectral studies revealed a hyperchromic effect and suggested the possible mode of interaction with CT-DNA. The competitive binding studies using ethidium bromide (EB) show that the complexes can replace DNA from DNA-EB adduct and suggests that the complexes probably bind to CT-DNA in intercalative mode. In vitro antibacterial activity of the complexes against Gram-negative bacteria Klebsiella pneumoniae (K. pneumoniae), Escherichia coli(E. coli), and Shigella boydii (S. boydii), and gram-positive bacteria Staphylococcus aureus (S. aureus) exhibited an appreciable antibacterial activity of complex 2 against K. pneumoniae and S. boydii, but complexes 1 and 3 did not show any significant antibacterial activity.
- Cu(Ⅱ) complex,
- Schiff base,
- structure,
- bio-activity,
- density functional theory
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