Citation: Donghui PAN, Yuping XU, Xinyu WANG, Lizhen WANG, Junjie YAN, Dongjian SHI, Min YANG, Mingqing CHEN. Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(4): 669-676. doi: 10.11862/CJIC.20230468 shu

Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging

Donghui PAN ^{1, 2} ,
Yuping XU ² ,
Xinyu WANG ² ,
Lizhen WANG ² ,
Junjie YAN ² ,
Dongjian SHI ¹ ,
Min YANG ^2,, ,
Mingqing CHEN ^1,,

1.
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, School of Chemical and Material Engineering, Wuxi, Jiangsu 214122, China
2.
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China

Corresponding author: Min YANG, yangmin@jsinm.org Mingqing CHEN, mqchen@jiangnan.edu.cn
Received Date: 13 December 2023
Revised Date: 11 March 2024

Figures(9)

Melanin nanoparticle (MNP) was modified by polyethylene glycols (PEG), and the resulting compound (PEG-MNP) was obtained. The ⁶⁸Ga labeled PEG-MNP was prepared by chelating radioactive ⁶⁸Ga³⁺ ions with high labeling yield (95.6%±1.9%) and radiochemical purity (>95%). The stability of the labeling compound as well. Then ⁶⁸Ga-PEG-MNP for simulating PM_2.5 particles (particulate matter 2.5, size < 2.5 μm) was obtained through nebulization. After inhaling the nebulized particles, whole-body positron emission tomography (PET) in mice was performed. It revealed that nebulized ⁶⁸Ga - PEG - MNP diffused from the trachea to the bilateral lobe area of the lungs and retained in the lungs. Quantification of PET images showed that the uptakes of the trachea and lung were (7.20±2.44)%·g^-1, (4.46±1.04)%·g^-1, (4.91±2.48)%·g^-1, (4.71±2.39)%·g^-1, (3.34±1.14)%·g^-1, and (17.90±3.75)%·g^-1, (18.10±4.52)%·g^-1, (19.49±6.11)%·g^-1, (19.19±2.83)%·g^-1, (20.87±2.40)%·g^-1 at 0 min, 30 min, 1 h, 2 h, 4 h after administration of the nebulized ⁶⁸Ga-PEG-MNP, respectively. The results were highly consistent with the findings of ex-vivo radiographic autoradiography.
- positron emission tomography,
- ⁶⁸Ga,
- melanin nanoparticle,
- PM_2.5
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Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging