Citation: Botao QU, Qian WANG, Xiaogang NING, Yuxin ZHOU, Ruiping ZHANG. Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(5): 1025-1032. doi: 10.11862/CJIC.20230416 shu

Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle

Botao QU ^{1, #} ,
Qian WANG ^{2, #} ,
Xiaogang NING ^{3, #} ,
Yuxin ZHOU ¹ ,
Ruiping ZHANG ^4,,

1.
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
2.
School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China
3.
School of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, China
4.
The Radiology Department of First Hospital of Shanxi Medical University, Taiyuan 030001, China

Corresponding author: Ruiping ZHANG, beyondthj@163.com; zrp_7142@sxmu.edu.cn
Received Date: 1 November 2023
Revised Date: 6 March 2024

Figures(5)

A dual-targeting melanin nanoparticle (MNP-TPP-HA) was constructed by grafting the carboxyl groups of hyaluronic acid (HA) and (4-carboxybutyl) triphenylphosphonium bromide (TPP) onto the surface of polyethylene glycol-amino (PEG-NH₂) modified MNP based on 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxy succinimide (NHS) reaction, endowing melanin with the ability of dual active targeting. The fluorescence imaging of in vitro three-dimensional (3D) tumor models and in vivo photoacoustic imaging (PAI) all reveal the excellent target penetration ability of MNP-TPP-HA.
- dual-targeting,
- melanin,
- photoacoustic imaging,
- penetration ability
1. [1]
  Hanahan D, Weinberg R A. Hallmarks of cancer: The next generation[J]. Cell, 2011,144(5):646-674. doi: 10.1016/j.cell.2011.02.013
2. [2]
  Giraldo N A, Sanchez-Salas R, Peske J D, Vano Y, Becht E, Petitprez F, Validire P, Ingels A, Cathelineau X, Fridman W H, Sautès-Fridman C. The clinical role of the TME in solid cancer[J]. Br. J. Cancer, 2019,120(1):45-53. doi: 10.1038/s41416-018-0327-z
3. [3]
  Gong F, Yang N L, Wang X W, Zhao Q, Chen Q, Liu Z, Cheng L. Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics[J]. Nano Today, 2020,32100851. doi: 10.1016/j.nantod.2020.100851
4. [4]
  Ortiz R, Quinonero F, Garcia-Pinel B, Fuel M, Mesas C, Cabeza L, Melguizo C, Prados J. Nanomedicine to overcome multidrug resistance mechanisms in colon and pancreatic cancer: Recent progress[J]. Cancers, 2021,13(9)2058. doi: 10.3390/cancers13092058
5. [5]
  Mura S, Couvreur P. Nanotheranostics for personalized medicine[J]. Adv. Drug Deliv. Rev., 2012,64(13):1394-1416. doi: 10.1016/j.addr.2012.06.006
6. [6]
  Overchuk M, Zheng G. Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics[J]. Biomaterials, 2018,156:217-237. doi: 10.1016/j.biomaterials.2017.10.024
7. [7]
  Certo M, Tsai C H, Pucino V, Ho P C, Mauro C. Lactate modulation of immune responses in inflammatory versus tumour microenvironments[J]. Nat. Rev. Immunol., 2021,21(3):151-161. doi: 10.1038/s41577-020-0406-2
8. [8]
  Roma-Rodrigues C, Pombo I, Raposo L, Pedrosa P, Fernandes A R, Baptista P V. Nanotheranostics targeting the tumor microenvironment[J]. Front. Bioeng. Biotechnol., 2019,7197. doi: 10.3389/fbioe.2019.00197
9. [9]
  Sikkandhar M G, Nedumaran A M, Ravichandar R, Singh S, Santhakumar I, Goh Z C, Mishra S, Archunan G, Gulyás B, Padmanabhan P. Theranostic probes for targeting tumor microenvironment: An overview[J]. Int. J. Mol. Sci., 2017,18(5)1036. doi: 10.3390/ijms18051036
10. [10]
  d'Ischia M, Napolitano A, Pezzella A, Meredith P, Buehler M. Melanin biopolymers: Tailoring chemical complexity for materials design[J]. Angew. Chem. Int. Ed., 2020,59(28):11196-11205. doi: 10.1002/anie.201914276
11. [11]
  Qi C, Fu L H, Xu H, Wang T F, Lin J, Huang P. Melanin/polydopamine-based nanomaterials for biomedical applications[J]. Sci. China-Chem., 2019,62(2):162-188. doi: 10.1007/s11426-018-9392-6
12. [12]
  Qu B T, Zhang X M, Han Y H, Peng X Y, Sun J H, Zhang R P. IR820 functionalized melanin nanoplates for dual-modal imaging and photothermal tumor eradication[J]. Nanoscale Adv., 2020,2(6):2587-2594. doi: 10.1039/D0NA00236D
13. [13]
  Caldas M, Santos A C, Veiga F, Rebelo R, Reis R L, Correlo V M. Melanin nanoparticles as a promising tool for biomedical applications-a review[J]. Acta Biomater., 2020,105:26-43. doi: 10.1016/j.actbio.2020.01.044
14. [14]
  Longo D L, Stefania R, Aime S, Oraevsky A. Melanin-based contrast agents for biomedical optoacoustic imaging and theranostic applications[J]. Int. J. Mol. Sci., 2017,18(8)1719. doi: 10.3390/ijms18081719
15. [15]
  Liu Y L, Ai K L, Ji X Y, Askhatova D, Du R, Lu L H, Shi J J. Comprehensive insights into the multi-antioxidative mechanisms of melanin nanoparticles and their application to protect brain from injury in ischemic stroke[J]. J. Am. Chem. Soc., 2017,139(2):856-862. doi: 10.1021/jacs.6b11013
16. [16]
  Bayer I S. Hyaluronic acid and controlled release: A review[J]. Molecules, 2020,25(11)2649. doi: 10.3390/molecules25112649
17. [17]
  Lei C, Liu X R, Chen Q B, Li Y, Zhou J L, Zhou L Y, Zou T. Hyaluronic acid and albumin based nanoparticles for drug delivery[J]. J. Control. Release, 2021,331:416-433. doi: 10.1016/j.jconrel.2021.01.033
18. [18]
  Cheng X X, Feng D, Lv J Y, Cui X M, Wang Y C, Wang Q, Zhang L. Application prospects of triphenylphosphine-based mitochondria- targeted cancer therapy[J]. Cancers, 2023,15(3)666. doi: 10.3390/cancers15030666
19. [19]
  Gong N Q, Ma X W, Ye X X, Zhou Q F, Chen X A, Tan X L, Yao S K, Huo S D, Zhang T B, Chen S Z, Teng X C, Hu X X, Yu J, Gan Y L, Jiang H D, Li J H, Liang X J. Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment[J]. Nat. Nanotechnol., 2019,14(4):379-387. doi: 10.1038/s41565-019-0373-6
20. [20]
  Mattheolabakis G, Milane L, Singh A, Amiji M M. Hyaluronic acid targeting of CD44 for cancer therapy: From receptor biology to nanomedicine[J]. J. Drug Target., 2015,23(7/8):605-618.
21. [21]
  Feng G X, Qin W, Hu Q L, Tang B Z, Liu B. Cellular and mitochondrial dual-targeted organic dots with aggregation-induced emission characteristics for image-guided photodynamic therapy[J]. Adv. Healthc. Mater., 2015,4(17):2667-2676. doi: 10.1002/adhm.201500431
22. [22]
  Luo Z J, Dai Y, Gao H L. Development and application of hyaluronic acid in tumor targeting drug delivery[J]. Acta Pharm. Sin. B, 2019,9(6):1099-1112. doi: 10.1016/j.apsb.2019.06.004
23. [23]
  Tripodo G, Trapani A, Torre M L, Giammona G, Trapani G, Mandracchia D. Hyaluronic acid and its derivatives in drug delivery and imaging: Recent advances and challenges[J]. Eur. J. Pharm. Biopharm., 2015,97(Part B):400-416.
24. [24]
  Ashrafizadeh M, Mirzaei S, Gholami M H, Hashemi F, Zabolian A, Raei M, Hushmandi K, Zarrabi A, Voelcker N H, Aref A R, Hamblin M R, Varma R S, Samarghandian S, Arostegi I J, Alzola M, Kumar A P, Thakur V K, Nabavi N, Makvandi P, Tay F R, Orive G. Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli‐responsive carriers, co-delivery and resistance suppression[J]. Carbohydr. Polym., 2021,272118491. doi: 10.1016/j.carbpol.2021.118491
25. [25]
  Hu Q L, Gao M, Feng G X, Liu B. Mitochondria-targeted cancer therapy using a light-up probe with aggregation-induced-emission characteristics[J]. Angew. Chem. Int. Ed., 2014,53(51):14225-14229. doi: 10.1002/anie.201408897
26. [26]
  Li F, Liu Y J, Dong Y H, Chu Y W, Song N C, Yang D Y. Dynamic assembly of DNA nanostructures in living cells for mitochondrial interference[J]. J. Am. Chem. Soc., 2022,144(10):4667-4677. doi: 10.1021/jacs.2c00823
27. [27]
  Chang X W, Tang X Y, Liu J, Zhu Z R, Mu W Y, Tang W J, Zhang Y M, Chen X. Precise starving therapy via physiologically dependent photothermal conversion promoted mitochondrial calcification based on multi‐functional gold nanoparticles for effective tumor treatment[J]. Adv. Funct. Mater., 2023,33(35)2303596. doi: 10.1002/adfm.202303596
28. [28]
  ZHANG C L, ZHANG J J, SHEN Y, LU J C, HUANG F, XU L. A rapid response of mitochondrial targeted fluorescent probe for detecting living cells and hypochlorite in zebrafish[J]. Chinese J. Inorg. Chem., 2022,38(8):1623-1632.
29. [29]
  Zhang R P, Fan Q L, Yang M, Cheng K, Lu X M, Zhang L, Huang W, Cheng Z. Engineering melanin nanoparticles as an efficient drug-delivery system for imaging-guided chemotherapy[J]. Adv. Mater., 2015,27(34):5063-5069. doi: 10.1002/adma.201502201
30. [30]
  Pieper J S, Hafmans T, Veerkamp J H, van Kuppevelt T H. Development of tailor-made collagen-glycosaminoglycan matrices: EDC/NHS crosslinking, and ultrastructural aspects[J]. Biomaterials, 2000,21(6):581-593. doi: 10.1016/S0142-9612(99)00222-7
31. [31]
  Li Q Q, Liu L T, Huo H Q, Su L C, Wu Y, Lin H X, Ge X G, Mu J, Zhang X, Zheng L T, Song J B. Nanosized Janus AuNR-Pt motor for enhancing NIR-II photoacoustic imaging of deep tumor and Pt²⁺ ion-based chemotherapy[J]. ACS Nano, 2022,16(5):7947-7960. doi: 10.1021/acsnano.2c00732
32. [32]
  ZHANG P G, YU D C, CHENG Z W, HE Z P, ZHANG X H, LI H L, ZHANG H Q. Application of folate receptor-targeted CdS quantum dots in imaging of HepG2 cells[J]. Chinese J. Inorg. Chem., 2007,23(9):1662-1666. doi: 10.3321/j.issn:1001-4861.2007.09.031
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