Citation: Kang XIAO, Wang-Wang XIE, Xiang-Mei LIU. Preparation of nanoscale hafnium-containing metal-organic frameworks for X-ray-promoted chemodynamic synergistic therapy[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(11): 2033-2041. doi: 10.11862/CJIC.2023.171 shu

Preparation of nanoscale hafnium-containing metal-organic frameworks for X-ray-promoted chemodynamic synergistic therapy

State Key Laboratory of Organic Electronics and Information Displays, School of Materials Science & Engineering, Nanjing University of Posts & Telecommunications, Nanjing 210023, China

Corresponding author: Xiang-Mei LIU, iamxmliu@njupt.edu.cn
Received Date: 23 April 2023
Revised Date: 8 September 2023

Figures(6)

Nanoscale hafnium-containing metal-organic frameworks (Hf-nMOFs) with octahedral (Hf-MOFs-1) and sheet-like (Hf-MOFs-2) structures were synthesized by a solvothermal method using hafnium clusters as the connection point of the MOF, rigid dicarboxylic ligand 2, 2'-bipyridyl-5, 5'-dicarboxylic acid as the connector, acetic acid or trifluoroacetic acid and water as the structural regulator. Subsequently, a post-modification method was used to incorporate Fe³⁺ into the backbone of Hf-nMOFs, leading to the creation of multifunctional nMOFs, designated as Hf-Fe-MOFs-1 and Hf-Fe-MOFs-2. In a mimic tumor microenvironment, the detection of hydroxyl radicals showed that X-ray irradiation significantly increased the generation efficiency of hydroxyl radicals in both Hf-Fe-MOFs-1 and Hf-Fe-MOFs-2, with a more generation ability of sheet-like Hf-Fe-MOFs-2 than that of octahedral Hf-Fe-MOFs-1. Additionally, cellular assays demonstrated successful uptake of the Hf-nMOFs by cells and confirmed their efficacy in achieving low-dose X-ray-promoted chemodynamic synergistic therapy.
- hafnium-containing metal-organic frameworks,
- Fenton reaction,
- hydroxyl radical,
- chemodynamic therapy,
- synergistic therapy
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