Citation: Bing-Lian GUO, Ji LI, Meng-Di LÜ, Xu-Ling XUE, Hong-Ke LIU. Synthesis and anticancer mechanism of ferroptosis of binuclear Os(Ⅱ)-arene complex[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(10): 1887-1897. doi: 10.11862/CJIC.2023.160 shu

Synthesis and anticancer mechanism of ferroptosis of binuclear Os(Ⅱ)-arene complex

School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China

Corresponding author: Xu-Ling XUE, xuexuling87@163.com Hong-Ke LIU, liuhongke@njnu.edu.cn
Received Date: 19 April 2023
Revised Date: 6 September 2023

Figures(10)

Here, we describe [Os(η⁶-bip)(1, 3-bib)Cl]₂Cl₂ (bib-Os) (η⁶-bip=η⁶-biphenyl, 1, 3-bib=1, 3-di(1H-imidazol-1-yl) benzene), a binuclear Os(Ⅱ) complex, which was characterized by ¹H NMR and ESI-MS. The results showed that complex bib-Os had good lipophilicity (lg P_o/w=1.52) and was easy to accumulate in cells. Complex bib-Os showed high antiproliferative activity against human ovarian A2780 cancer cells (IC₅₀=4.2 μmol·L^-1), producing a large number of reactive oxygen species (ROS) and inducing mitochondrial morphological damage and membrane potential decline. Lipid peroxide (LPO) accumulation, glutathione (GSH) depletion, and glutathione peroxidase 4 (GPX4) inhibition further verified bib-Os-induced cell death through the ferroptosis pathway.
- Os(Ⅱ)-arene complex,
- binuclear,
- mitochondrial damage,
- ferroptosis
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