Citation: Bo SUN, Ning ZHAO, Xin XU, Lai JIANG, Feng LU, Qu-Li FAN, Wei HUANG. Synthesis of Fe-doped CuS nanoparticles for the combination of photothermal and chemodynamic therapy[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(4): 671-679. doi: 10.11862/CJIC.2023.026 shu

Synthesis of Fe-doped CuS nanoparticles for the combination of photothermal and chemodynamic therapy

Bo SUN ¹ ,
Ning ZHAO ¹ ,
Xin XU ¹ ,
Lai JIANG ¹ ,
Feng LU ^1,, ,
Qu-Li FAN ^1,, ,
Wei HUANG ^{1, 2}

1.
State Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, China
2.
Institute of Flexible Electronics, Northwestern Polytechnical University, Xi'an 710072, China

Corresponding author: Feng LU, iamflu@njupt.edu.cn Qu-Li FAN, iamqlfan@njupt.edu.cn
Received Date: 12 October 2022
Revised Date: 10 February 2023

Figures(6)

Copper sulfide (CuS) nanoparticles with strong absorption in the near-infrared region were synthesized in oleic acid (OA)-oleylamine (OM)-octadecene (ODE) system using copper acetylacetonate and sulfur powder as copper and sulfur sources respectively.By adjusting the activation solvent for the sulfur powder, the absorption peak can be tuned to around 1 064 nm which was beneficial for photothermal therapy.The Fe and Mn elements doped CuS nanoparticles were further prepared by the cation exchange approach, and the absorption peak can be retained after the reaction.Then, these hydrophobic nanoparticles were transferred into an aqueous solution by the microemulsion method, the obtained PEGylated (PEG=poly (ethylene glycol)) nanoparticles exhibited excellent dispersity and colloidal stability.Their photothermal performance and the hydroxyl radical (·OH) production before and after Fe³⁺ doping were investigated thereafter.The mass extinction coefficient of Fe³⁺ doped CuS nanoparticles after PEGylation (CuS∶FePEG) at 1064 nm was 37.5 L·g^-1·cm^-1, with a high photothermal conversion efficiency of around 43.7%.Although these values were slightly decreased compared with undoped CuS-PEG, their ability to produce ·OH was significantly improved.A higher inhibition ratio of cancer cells was observed with CuS∶FePEG nanoparticles under weak acid condition.And under 1 064 nm laser, these nanoparticles can kill cancer cells more effectively.Therefore, the prepared CuS∶Fe-PEG nanoparticles can be used for the combination of photothermal and chemodynamic therapy.
- CuS,
- cation exchange,
- photothermal therapy,
- Fenton reaction
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