Citation: Le CHEN, Xin DENG, Yu-Xing TAN, Fu-Xing ZHANG, Dai-Zhi KUANG, Wu-Jiu JIANG. Synthesis, Anti⁃tumor Activity, and Interaction with DNA of Two Substituted Benzyltin Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(6): 1081-1089. doi: 10.11862/CJIC.2022.124 shu

Synthesis, Anti⁃tumor Activity, and Interaction with DNA of Two Substituted Benzyltin Complexes

Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials of College of Hunan Province, Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Yu-Xing TAN, tanyuxing@hynu.edu.cn Wu-Jiu JIANG, jwj_china@163.com
Received Date: 30 November 2021
Revised Date: 12 April 2022

Figures(10)

Two organotin complexes (C1, C2) were synthesized by di(2, 4-dichlorobenzyl)tin dichloride reacting with p-methyl benzoyl hydrazide or p-tert-butyl benzoyl hydrazide, and sodium pyruvate. The structure of the complexes were characterized through elemental analysis, IR, ¹H NMR, ¹³C NMR, ¹¹⁹Sn NMR, HRMS, and X-ray single crystal diffraction. The thermal stability of complexes C1 and C2 were analyzed, and the antitumor activities of the complexes were evaluated by MTT against three cell lines (human lung cancer cells NCI-H460, human liver cancer cells HepG2, and human breast cancer cells MCF7). It was found that complex C1 showed a good inhibitory effect on NCI-H460, HepG2, and MCF7. The interaction of the complexes with DNA was investigated using UV-Vis spectroscopy, fluorescence spectroscopy, and viscosity measurement. It is found that the complexes can bind to DNA through an intercalation mode. CCDC: 2124763, C1; 2124764, C2.
- organotin complex,
- synthesis,
- crystal structure,
- antitumor activities,
- deoxyribonucleic acid
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