Citation: Xiu-Juan JIANG, Zhi-Yin XIAO, Li LONG, Li-Mei CHEN, Li-Qiu ZHANG, Xiao-Ming LIU. Interactions of a Water-Soluble Diiron Hexacarbonyl Complex with Biologically Relevant Molecules and Their Promotion in CO-Release[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(5): 913-920. doi: 10.11862/CJIC.2022.083 shu

Interactions of a Water-Soluble Diiron Hexacarbonyl Complex with Biologically Relevant Molecules and Their Promotion in CO-Release

College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, Zhejiang 314001, China

Corresponding author: Xiu-Juan JIANG, jiangxj@mail.zjxu.edu.cn Xiao-Ming LIU, xiaoming.liu@mail.zjxu.edu.cn
Received Date: 8 September 2021
Revised Date: 13 February 2022

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In this study, a water-soluble diiron carbonyl complex, [Fe₂(μ-SCH₂R)₂(CO)₆] (R=CH(OH)CH₂(OH), 1), which has the potential as a CO-releasing molecule (CORM), was used to spectroscopically investigate its interaction with some biological molecules, such as hemoglobin (Hb), myoglobin (Mb), bovine serum albumin (BSA), glutathione (GSH), and DNA. The IR spectroscopic results showed that the proteins and GSH could promote the decomposition of complex 1 to release CO. All the CO-release progress followed the first-order kinetic model and GSH possessed the highest efficiency in promoting CO-release. UV absorption spectral variations and fluorescent quench effect also indicated the interactions between these biologically relevant molecules and the diiron carbonyl complex. CD spectra of the mixture of the proteins and complex 1 indicated that no conformational changes in the proteins are induced. The interactions between pUC19 plasmid DNA and complex 1 suggested that the complex could not cause DNA damage.
- CO-releasing molecule,
- diiron hexacarbonyl complex,
- proteins,
- water-soluble
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