Citation: Xi LIU, Fu-Xing ZHANG, Li-Fang HE, Da-Wei LI, Wei-Hong ZENG, Shu-Yun JIANG, Xia HE, Liang-Bing SHENG, Xiao-Ming ZHU. Synthesis, Structure and Antitumor Activity of Two Tris(o-bromobenzyl)tin Carboxylates[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(1): 46-52. doi: 10.11862/CJIC.2022.016 shu

Synthesis, Structure and Antitumor Activity of Two Tris(o-bromobenzyl)tin Carboxylates

Department of Chemistry and Material Science, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Fu-Xing ZHANG, zfx8056@163.com
Received Date: 9 June 2021
Revised Date: 21 October 2021

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Two organotin carboxylate compounds, tri(o-bromobenzyl)tin thiophene 2-carboxylate (1) and tri(o-bromobenzyl)tin cinnamate (2), have been synthesized. Compounds 1 and 2 were characterized by elemental analysis, IR spectroscopy, NMR (¹H, ¹³C, and ¹¹⁹Sn), thermogravimetric analysis, and single-crystal X-ray diffraction. The study on compounds 1 and 2 has been performed with quantum chemistry calculation and in vitro anticancer activity. The results showed that the tin atoms in compounds 1 and 2 have distorted tetrahedral geometry. Compounds 1 and 2 had strong inhibitory activities against human breast cancer cells (MCF - 7), human non - small cell cancer cells (A549), and human lung cancer cell lines (H460).
- tri(o-bromobenzyl)tin thiophene 2-carboxylate,
- tri(o-bromobenzyl)tin cinnamate,
- crystal structure,
- quantum chemistry,
- in vitro antitumor activity
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