Citation: Pei-Pei QIAO, Yue-Wei TIAN, Qing HE, Yong-Po ZHANG, Chun-Yan GAO, Jin-Zhong ZHAO, Wei-Jun DU. Synthesis, Structure and Anticancer Activity of Binuclear Polypyridine Nickel Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(10): 1738-1744. doi: 10.11862/CJIC.2021.207 shu

Synthesis, Structure and Anticancer Activity of Binuclear Polypyridine Nickel Complexes

1.
Department of Basic Sciences, Shanxi Agricultural University, Jinzhong, Shanxi 030801, China
2.
College of Agronomy, Shanxi Agricultural University, Jinzhong, Shanxi 030801, China

Corresponding author: Chun-Yan GAO, gaocynk@163.com Wei-Jun DU, duweijun68@126.com
Received Date: 2 February 2021
Revised Date: 16 July 2021

Figures(5)

Two new polypyridine dinuclear nickel (Ⅱ) complexes[Ni₂(L)₂Cl₂](ClO₄)₂·3H₂O (1) and[Ni₂(L)₂Cl₂](PF₆)₂ (2) (L=N, N-bis(pyridin-2-ylmethyl)-4-(4-((pyridin-2-ylmethyl)amino)benzyl)aniline) were synthesized, and their structures were determined by X-ray single crystal diffraction, elemental analysis and infrared spectroscopy. Moreover, the in vitro toxic effects of the two complexes on cancer cells (HeLa, BGC-823, NCI-H460, HepG-2) were tested by thiazole blue (MTT) method, and the results indicate that the two complexes showed good toxicity on NCIH460 cells. IC₅₀=(26.0±2.2) μmol·L^-1 (1), (31.3±2.7) μmol·L^-1 (2). The cytotoxic mechanism of complex 1 towards NCI-H460 cells was further explored by Hoechst 33342 staining, detection of intracellular reactive oxygen species levels and measurement of mitochondrial membrane potential change. The results demonstrate that complex 1 is likely to induce cell apoptosis through the mitochondrial pathway, thereby causing lethal effects on cancer cells.
- nickel complex,
- crystal structure,
- cytotoxicity,
- mitochondrial pathway
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