Citation: Jing-Jing ZHANG, Ming YAN, Wen LU, Li XU, Xiao-Qing WANG. Design, Synthesis and Fluorescence Imaging Application of Hypochlorite Probe Based on Coumarin-oxime[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(6): 1071-1079. doi: 10.11862/CJIC.2021.133 shu

Design, Synthesis and Fluorescence Imaging Application of Hypochlorite Probe Based on Coumarin-oxime

College of Science, Nanjing Forestry University, Nanjing 210093, China

Corresponding author: Li XU, xuliqby@njfu.edu.cn Xiao-Qing WANG, xqwang@njfu.edu.cn
Received Date: 22 January 2021
Revised Date: 27 April 2021

Figures(8)

We designed and synthesized a fluorescent probe for hypochlorite based on coumarin-oxime (Cou-HC). Not only Cou-HC showed a rapid and highly selective response to hypochlorite, but also the product after the probe oxidation did not react with biological thiols, which could avoid the interference of biological thiols on the response of hypochlorite. The results of cell imaging experiments showed that the probe could perform real-time imaging of endogenous and exogenous hypochlorite in RAW 264.7 cells, which proves the probe's ability to detect hypochlorite in living systems.
- fluorescent probe,
- hypochlorite,
- coumarin,
- fluorescence detection,
- cell imaging
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