Citation: Ai OUYANG, Yu-Heng LUO, Nong LU, Ren-Tao HU, Ping-Yu ZHANG, Qian-Ling ZHANG. Viscosity Responsive and Mitochondria Targeted Iridium(Ⅲ) Complexes for Photodynamic Therapy of Tumors[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(3): 401-411. doi: 10.11862/CJIC.2021.052 shu

Viscosity Responsive and Mitochondria Targeted Iridium(Ⅲ) Complexes for Photodynamic Therapy of Tumors

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518071, China

Corresponding author: Ping-Yu ZHANG, p.zhang6@szu.edu.cn Qian-Ling ZHANG, zhql@szu.edu.cn
Received Date: 27 July 2020
Revised Date: 17 December 2020

Figures(12)

Two novel iridium(Ⅲ) complexes (Ir1 and Ir2) containing rotatable groups were designed and synthesized for viscosity probes and photosensitizers. Firstly, they freely rotated and showed weak phosphorescence in lowviscosity environment, while in viscous media, the phosphorescence intensity increased significantly (35.7-fold for Ir1, 1 311.6 -fold for Ir2). The cellular uptake and co -localization studies indicated that the probes could easily cross the cell membrane and aggregate in mitochondria, and the results showed that they could be used for detection of mitochondrial viscosity. Moreover, Ir1 and Ir2 displayed high potent photo-cytotoxicity to cancer cells (A549 and Hep-G2) under light irradiation but exhibited lower photo-cytotoxicity to normal cells (MRC-5 and LO2). The generation of ¹O₂ under light irradiation were also measured by electron paramagnetic resonance (EPR) and confocal microscopy.
- iridium(Ⅲ) complexes,
- viscosity-response,
- mitochondria-targeting,
- photodynamic therapy
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