Citation: TAO Qin, WU Jian, GE Chao, WANG Meng-Meng, LÜ Meng-Di, XUE Xu-Ling, LIU Hong-Ke. Synthesis, Characterization, Fluorescence and Interactions with DNA/BSA Properties of Ruthenium Ferulate Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(10): 1853-1864. doi: 10.11862/CJIC.2020.214 shu

Synthesis, Characterization, Fluorescence and Interactions with DNA/BSA Properties of Ruthenium Ferulate Complexes

School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China

Corresponding author: XUE Xu-Ling, xuexuling87@163.com; LIU Hong-Ke, liuhongke@njnu.edu.cn
Received Date: 18 February 2020
Revised Date: 9 June 2020

Figures(7)

We synthesized two novel mononuclear ruthenium complexes, [Ru(cym)(L)Cl]Cl (Ru-1) and[Ru(bpy)₂(L)] Cl₂ (Ru-2) (cym=cymene, bpy=2, 2'-bipyridine, L=(E)-3-(4-hydroxy-3-methoxyphenyl)-N-((4'-methyl-(2, 2'-bipyridin)4-yl)methyl)acrylamide), with the modified natural product trans-ferulic acid. Their structures were determined by ¹H NMR, ¹³C NMR and ESI-MS techniques. Optical properties and lipophilicity of complexes were characterized by using the fluorescence and UV-visible spectra. The results suggested that both complexes exhibited high water solubility. Ru-2 showed good fluorescence performance with the maximum emission wavelength at 631 nm in the near infrared area and had pH responsive ability (pH=8~10). Additionally, Ru-2 exhibited high singlet oxygen quantum yield (Φ=0.70), which might be expected to become an efficient photosensitizer. Both of the complexes binded to CT -DNA through intercalation mode (K_b:1.210×10⁴ L·mol^-1 for Ru-1; 1.233×10³ L·mol^-1 for Ru-2) and interacted with BSA with one site, causing static quenching of their fluorescence (K_a:1.94×10⁴ for Ru-1; 2.45×10⁴ for Ru-2).
- ruthenium complex,
- pH responsive,
- interaction with BSA/DNA,
- singlet oxygen species
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