Citation: ZHONG Yu-Jun, CHEN Zhen-Feng, LIANG Hong. Synthesis, Structural Characterization and Antitumor Activity of Copper(Ⅱ) Complex of 4-(2-Hydroxy-3-chlorine)phenyl-2, 2': 6', 2'-terpyridine[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(11): 2089-2094. doi: 10.11862/CJIC.2019.253 shu

Synthesis, Structural Characterization and Antitumor Activity of Copper(Ⅱ) Complex of 4-(2-Hydroxy-3-chlorine)phenyl-2, 2': 6', 2'-terpyridine

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, Guangxi 541004, China

Corresponding author: CHEN Zhen-Feng, chenzf@gxnu.edu.cn LIANG Hong, hliang@gxnu.edu.cn
Received Date: 15 September 2019
Revised Date: 17 October 2019

Figures(6)

A new copper(Ⅱ) complex [Cu₂(μ-L-κO, O)₂Cl₂] (1) with 4-(2-hydroxy-3-chloro)phenyl-2, 2':6', 2'-tribi-pyridine(HL) as ligand was synthesized and characterized by elemental analysis, NMR, ESI-MS as well as single crystal X-ray diffraction analysis. Complex 1 is a binuclear structure, and the central copper(Ⅱ) is coordinated by one Cl^- anion, two N atoms and two hydroxyl O atoms from L^- to form five-coordination distorted square-pyramid geometric configurations; two copper centers are bridged by two hydroxyl O atoms. MTT assay was employed to test the inhibitory activities of complex 1 against five selected cancer cell lines. The results showed that inhibition rate of MGC80-3 cells was the highest, reaching(84.30±1.28)%, and its IC₅₀ value was(3.36±0.43) μmol·L^-1. Flow cytometry analytical results indicated that complex 1 could induce apoptosis of MGC80-3 cells. Under the complex 1 concentration of 4.5 μmol·L^-1, the MGC80-3 cell apoptosis percentage was 42.2%. Complex 1 arrested MGC80-3 cells in G1 phase, thereby inhibiting the growth of tumor cells.
- tribipyridine,
- copper(Ⅱ) complex,
- antitumor activity,
- cell apoptosis,
- cell cycle
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