Citation: CHEN Min-Min, GENG Hao-Ran, HU Jin-Xia, ZHANG Qiong, Godfred Amfo Agyekum, ZHANG Zhuo-Qi, CAO Xi-Chuan. Synthesis of Fluorescent Mesoporous Silica Nanoparticles and Application for Intracellular Drug Delivery[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(11): 2125-2135. doi: 10.11862/CJIC.2019.244 shu

Synthesis of Fluorescent Mesoporous Silica Nanoparticles and Application for Intracellular Drug Delivery

1.
School of Materials Science and Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221000, China
2.
School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou, Jiangsu 221000, China
3.
Department of Cardiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China

Corresponding author: ZHANG Zhuo-Qi, zhuoqizhang@sina.com CAO Xi-Chuan, xichuancao@cumt.edu.cn
Received Date: 13 August 2019
Revised Date: 4 October 2019

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Here, we reported the synthesis and FITC-functionalized of mesoporous silica nanoparticles (MSNs) for tracing bioimaging and sustained drug release. Firstly, the MSNs-FITC were synthesized through one-pot method and characterized by SEM, TEM, FT-IR, XRD and the N₂ adsorption-desorption isotherm respectively. Then a classic anticancer drug doxorubicin (DOX) was loaded into the MSNs-FITC. The DOX-loaded nanocarriers exhibited obviously pH dependent release behavior with accelerated release rate in acidic environment. Meanwhile, the in vitro cytotoxicity evaluation exhibited that the nude MSNs-FITC were highly biocompatible. Furthermore, the confocal laser scanning microscope (CLSM) images indicated that MSNs-FITC could penetrate into living cells effectively and dose-depended internalization of MSNs-FITC were further investigated by flow cytometry analysis (FCM).
- mesoporous silica nanocarriers,
- drug delivery,
- cytotoxicity,
- bioimaging
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沈阳化工大学材料科学与工程学院沈阳 110142