Citation: CHEN Yan-Min, XIE Qing-Fan. Two Nickel(Ⅱ) Complexes with Hydrazone Ligands: Hydrothermal Syntheses, Structures, Antitumor Activities and Quantum Chemical Calculation[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(9): 1602-1608. doi: 10.11862/CJIC.2019.180 shu

Two Nickel(Ⅱ) Complexes with Hydrazone Ligands: Hydrothermal Syntheses, Structures, Antitumor Activities and Quantum Chemical Calculation

CHEN Yan-Min ,
XIE Qing-Fan ^,

College of Chemical Engineering and Material, Quanzhou Normal University, Quanzhou, Fujian 362000, China

Corresponding author: XIE Qing-Fan, xqf360@163.com
Received Date: 29 April 2019
Revised Date: 4 June 2019

Figures(5)

Two nickel(Ⅱ) complexes[Ni(Lss)(Py)] (1) and[Ni₂(Lrr)₂(4, 4'-bipy)] (2) having different hydrazone ligand, where H₂Lss is 2-thiophenecarboxylic acid (2-hydroxly-5-nitro-benzylidene)-hydrazide, H₂Lrr is 2-thiophenecar-boxylic acid (2-hydroxly-5-bromo-benzylidene)-hydrazide, have been hydrothermally synthesized in presence of pyridine or 4, 4'-bipyridine as co-ligand and characterized by elemental analysis, FT-IR and electronic spectra. The structures of complexes have been accomplished by single crystal X-ray diffraction which results confirmed that the crystal of 1 belongs to the orthorhombic system, space group Pbca and the crystal of 2 belongs to the monoclinic system, space group P2₁/c. The antitumor activities in vitro of ligands and complexes were tested by MTT method, which results show that 1 and 2 have strong in vitro antitumor activity against human acute promyelocytic leukemia cells HL-60. The quantum chemical calculation for the complex 2 was performed by means of Gaussian 09 program at B3LYP/6-31G(d) basis set.
- acylhydrazone,
- nickel complexes,
- crystal structure,
- antitumor activity,
- quantum chemistry calculation
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