Citation: LIU Shi-Shi, PENG Hong-Xia, HU Ji-Lin, HE Ai-Lan, CHEN Zhan-Jun, PENG Yang-Xi. Mesoporous Fe₃O₄@mMoO₃ Multifunctional Nanocarriers: Preparation and Microwave Response Drug Delivery[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(7): 1155-1162. doi: 10.11862/CJIC.2019.139 shu

Mesoporous Fe₃O₄@mMoO₃ Multifunctional Nanocarriers: Preparation and Microwave Response Drug Delivery

1.
Human Provincial Key Laboratory of Fine Ceramics and Powder Materials, School of Materials and Environmental Engineering, Human University of Humanities, Science and Technology, Loudi, Hunan 417000, China
2.
School of Materials Science and Engineering, Central South University, Changsha 410000, China

Corresponding author: PENG Hong-Xia, penghongxia1@126.com
Received Date: 22 December 2018
Revised Date: 19 April 2019

Figures(8)

The porous Fe₃O₄@mMoO₃ multifunctional core-shell nanoparticles were used to microwave-triggered controlled-release drug delivery systems. We also studied its magnetic-microwave heat transfer property and large specific surface area. We chose ibuprofen (IBU) as a model drug to evaluate the loading and release function of the Fe₃O₄@mMoO₃ nanoparticles, and used a direct precipitation method and thermal decomposition of C₁₉H₄₂BrN (CTAB) template method to synthesize core-shell structured Fe₃O₄@mMoO₃ nanoparticles. The specific surface areas were calculated by the Brunauer-Emmett-Teller (BET) method. The drug loading and controlled release of the Fe₃O₄@mMoO₃ triggered by microwave was determined with ultraviolet-visible spectroscopic analysis. The Fe₃O₄@mMoO₃ nanoparticles possessed high surface area of 94 cm²·g^-1, provided large accessible pore diameter of 2.5 nm for adsorption of drug molecules, high magnetization saturation value of 42.3 emu·g^-1 for drug targeting under foreign magnetic fields, and quickly converted electromagnetic energy into thermal energy for controlled release by microwave-triggered which was caused by mMoO₃ shell. The release amount of IBU was over 90% within 90 s under microwave discontinuous irradiation and outclassed that under the only stirring. This multifunctional material showed good performance for targeting delivery and microwave controlled release of anticancer drugs. The porous shell and the introduction of absorbing material not only increased the drug loading efficiency of the nanoparticles but also realized the microwave-stimulated anticancer drug controlled release.
- mesoporous materials,
- magnetic property,
- microwave chemistry,
- drug delivery
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沈阳化工大学材料科学与工程学院沈阳 110142

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Mesoporous Fe₃O₄@mMoO₃ Multifunctional Nanocarriers: Preparation and Microwave Response Drug Delivery