Citation: XIE Yun-Fu, YU Yang, TANG Liang-Fu. Syntheses, Structures and Antitumor Activities of Organotin 5-Methyl/amino-1H-tetrazolyl-1-acetates[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(12): 2291-2297. doi: 10.11862/CJIC.2018.273 shu

Syntheses, Structures and Antitumor Activities of Organotin 5-Methyl/amino-1H-tetrazolyl-1-acetates

1.
College of Science, Tianjin University of Science and Technology, Tianjin 300457, China
2.
State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

Corresponding author: TANG Liang-Fu, lftang@nankai.edu.cn
Received Date: 25 August 2018
Revised Date: 29 September 2018

Figures(4)

Five triorganotin 5-methyl-1H-tetrazolyl-1-acetates and 5-amino-1H-tetrazolyl-1-acetates have been synthesized by the reaction of (R₃Sn)₂O (R=Ph or n-Bu) or Cy₃SnOH (Cy=cyclohexyl) with 5-methyl-1H-tetrazolyl-1-acetic acid or 5-amino-1H-tetrazolyl-1-acetic acid. All the complexes were characterized by elemental analysis, IR and multinuclear NMR (¹H, ¹³C and ¹¹⁹Sn). Their structures have been confirmed by the X-ray single crystal diffraction analysis, suggesting that they form linkage coordination polymers through the intermolecular Sn…N interactions. The cytotoxic activity of the complexes for Hela and A549 cells was tested, showing that most of them displayed good cytotoxicities for these two cells in vitro.
- nitrogen-containing ligand,
- organotin carboxylate,
- X-ray crystal structure,
- antitumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142