Citation: HASI Qi-Mei-Ge, CHEN Li-Hua, XIAO Chao-Hu. Syntheses, DNA-binding and Antitumor Activities of Water Soluble Copper Porphyrins Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(10): 1841-1850. doi: 10.11862/CJIC.2018.239 shu

Syntheses, DNA-binding and Antitumor Activities of Water Soluble Copper Porphyrins Complexes

Experimental Center, Northwest Minzu University, Lanzhou 730070, China

Corresponding author: HASI Qi-Mei-Ge, ha2qimei@163.com
Received Date: 28 May 2018
Revised Date: 23 July 2018

Figures(8)

Three water-soluble copper porphyrin complexes (water-soluble bromine-containing copper porphyrin CuP-1 and its bromine substituted derivatives CuP-2 and CuP-3) have been synthesized and characterized by ¹H NMR, elementary analysis and MS spectra. The interaction of CuP-1, CuP-2 and CuP-3 with CT-DNA have been investigated by UV spectrum, EB-DNA fluorescence quenching, viscosity method and circular dichroism spectrum. Moreover, the antitumor activities of CuP-1~CuP-3 against Hela (cervical cancer) cell lines and MDA (breast carcinoma) cell lines have been studied by MTT assay. L929 (human fibroblast) cell line was used as a normal cell lines. Various spectroscopic approaches indicates that CuP-1 could effectively bind with CT-DNA through intercalation mode, while CuP-2 and CuP-3 may interact with CT-DNA by outside groove binding mode. And the binding affinity of CuP-1 with CT-DNA is better than its derivatives CuP-2 and CuP-3. In vitro antitumor activity experiments showed that CuP-1~CuP-3 can inhibit the growth of Hela and MDA cell lines, and the inhibition shows concentration and time dependent. In addition, antitumor activity in vitro of CuP-1 is much better than CuP-2 and CuP-3.
- water soluble copper porphyrins complexes,
- CT-DNA,
- anticancer activity
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