Citation: MA Xiao-Yu, LIU Yong-Jia, ZHU Bang-Shang. Preparation and Drug Delivery Properties of Mg-Doped Hydroxyapatite Nanoparticles[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(5): 917-924. doi: 10.11862/CJIC.2018.106 shu

Preparation and Drug Delivery Properties of Mg-Doped Hydroxyapatite Nanoparticles

1.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
2.
Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China

Corresponding author: ZHU Bang-Shang, bshzhu@sjtu.edu.cn
Received Date: 24 November 2017
Revised Date: 26 January 2018

Figures(9)

Magnesium-doped hydroxyapatites nanoparticles (Mg-HAs) with different feeding molar ratios were synthesized by step precipitation reaction and one pot reaction. The morphology and size of the Mg-HAs were controlled by different feeding molar ratio of magnesium nitrate and calcium nitrate. The Mg-HAs were characterized by transmission electron microscope, X-ray diffraction, et al. MTT method was used to evaluated in vitro cytotoxicity of the Mg-HAs. Results show that the synthesized Mg-HAs had the frame with fiber like structure, high specific surface area and low cell cytotoxicity. Mg-HAs as drug carrier material and cisplatin (cDDP) as a model drug were investigated, and the max loading rate was 54.84%. The drug loading Mg-HAs also have release properties (the releasing rate is 41.72% after 72 h), and a better inhibitory effect on cancer cells.
- magnesium doped hydroxyapatite,
- step reaction,
- cisplatin,
- drug loading
1. [1]
  Iijima M, Moriwaki Y, Yamaguchi R, et al. Connect. Tissue Res., 1997, 36(2):73-83 doi: 10.3109/03008209709160215
2. [2]
  Vallet-Regí M, González-Calbet J M. Prog. Solid State Chem., 2004, 32(1):1-31
3. [3]
  Wang L, Nancollas G H. Chem. Rev., 2008, 108(11):4628-4669 doi: 10.1021/cr0782574
4. [4]
  Dorozhkin S V. Biomaterials, 2010, 31(7):1465-1485 doi: 10.1016/j.biomaterials.2009.11.050
5. [5]
  Zhao J, Duan K, Zhang J W, et al. Mater. Sci. Eng., C, 2011, 31(3):697-701 doi: 10.1016/j.msec.2010.12.011
6. [6]
  Fathi M H, Hanifi A, Mortazavi V. J. Mater. Process. Technol., 2008, 202(1/2/3):536-542
7. [7]
  Abdulkareem E H, Memarzadeh K, Allaker R P, et al. J. Dent., 2015, 43(12):1462-1469 doi: 10.1016/j.jdent.2015.10.010
8. [8]
  Ye F, Guo H, Zhang H, et al. Acta Biomater., 2010, 6(6):2212-2218 doi: 10.1016/j.actbio.2009.12.014
9. [9]
  Sun R, Chen K, Lu Y. Mater. Res. Bull., 2009, 44(10):1939-1942 doi: 10.1016/j.materresbull.2009.06.015
10. [10]
  Zhao Q F, Wang T Y, Wang J, et al. Appl. Surf. Sci., 2011, 257(23):10126-10133 doi: 10.1016/j.apsusc.2011.06.161
11. [11]
  Gomes S, Nedelec J M, Jallot E, et al. Chem. Mater., 2011, 23(12):3072-3085 doi: 10.1021/cm200537v
12. [12]
  Murata H, Shitara K, Tanaka I, et al. J. Phys.:Condens. Matter, 2010, 22(38):384213-384218 doi: 10.1088/0953-8984/22/38/384213
13. [13]
  Evis Z, Webster T J. Adv. Appl. Ceram., 2011, 110(5):311-320 doi: 10.1179/1743676110Y.0000000005
14. [14]
  Webster T J, Massa-Schlueter E A, Smith J L, et al. Biomaterials, 2004, 25(11):2111-2121 doi: 10.1016/j.biomaterials.2003.09.001
15. [15]
  ZHAO Hong-Xia, JIN Hua, CAI Ji-Ye. Chinese J. Inorg. Chem., 2010, 26(1):106-111
16. [16]
  YAO Ai-Hua, XU Wei, AI Fan Rong, et al. J. Inorg. Mater., 2011, 26(9):974-978
17. [17]
  Niki Y, Matsumoto H, Suda Y, et al. Biomaterials, 2003, 24(8):1447-1457 doi: 10.1016/S0142-9612(02)00531-8
18. [18]
  Kalita S J, Bhatt H A. Mater. Sci. Eng., C, 2007, 27(4):837-848 doi: 10.1016/j.msec.2006.09.036
19. [19]
  Suchanek W L, Byrappa K, Shuk P, et al. Biomaterials, 2004, 25(19):4647-4657 doi: 10.1016/j.biomaterials.2003.12.008
20. [20]
  Kim S R, Lee J H, Kim Y T, et al. Biomaterials, 2003, 24(8):1389-1398 doi: 10.1016/S0142-9612(02)00523-9
21. [21]
  Landi E, Logroscino G, Proietti L, et al. J. Mater. Sci.-Mater. Med., 2008, 19(1):239-247 doi: 10.1007/s10856-006-0032-y
22. [22]
  Bigi A, Falini G, Foresti E, et al. J. Inorg. Biochem., 1993, 49(1):69-78 doi: 10.1016/0162-0134(93)80049-F
23. [23]
  Wan Y Z, Huang Y, He F, et al. Surf. Coat. Technol., 2006, 201(6):2904-2909 doi: 10.1016/j.surfcoat.2006.06.004
24. [24]
  Zhang X J, Lin D Y, Yan X H, et al. J. Cryst. Growth, 2011, 336(1):60-66 doi: 10.1016/j.jcrysgro.2011.09.039
25. [25]
  Ren F, Leng Y, Xin R, et al. Acta Biomater., 2010, 6(7):2787-2796 doi: 10.1016/j.actbio.2009.12.044
26. [26]
  Yuan X Y, Zhu B S, Tong G S, et al. J. Mater. Chem. B, 2013, 1(47):6551-6559 doi: 10.1039/c3tb21315c
27. [27]
  Eslami H, Solati-Hashjin M, Tahriri M. Journal of Ceramic Processing Research, 2008, 9(3):224-229
28. [28]
  Ren F, Leng Y R, Ge X. Acta Biomater., 2010, 6(7):2787-2796 doi: 10.1016/j.actbio.2009.12.044
29. [29]
  Kawasaki T, Niikura M, Kobayashi Y. J. Chromatogr. A, 1990, 515:125-148 doi: 10.1016/S0021-9673(01)89307-9
30. [30]
  Ulbrich K, Etrych T, Chytil P, et al. Adv. Drug Delivery Rev., 2004, 277(1/2):63-72
31. [31]
  Kratz F, Beyer U, Schütte M T. Crit. Rev. Ther. Drug Carrier Syst., 1999, 16(3):245-248 doi: 10.1615/CritRevTherDrugCarrierSyst.v16.i3
32. [32]
  Rodrigues P C, Roth T, Fiebig H, et al. Bioorg. Med. Chem., 2006, 14(12):4110-4117 doi: 10.1016/j.bmc.2006.02.007
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沈阳化工大学材料科学与工程学院沈阳 110142