Citation: ZHANG Zhi-Jian, JIANG Wu-Jiu, TAN Yu-Xing, LIU Yang, ZHU Xiao-Ming, ZHANG Fu-Xing, KUANG Dai-Zhi. Syntheses,Crystal Structures and Biological Activity of the 2-Oxo-propionic Acid Aroyl Hydrazone Di-4-methylbenzyltin Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2016, 32(11): 2003-2011. doi: 10.11862/CJIC.2016.266 shu

Syntheses,Crystal Structures and Biological Activity of the 2-Oxo-propionic Acid Aroyl Hydrazone Di-4-methylbenzyltin Complexes

1.
Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province;College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: ZHANG Zhi-Jian,
Received Date: 2 July 2016
Available Online: 7 October 2016
Fund Project:

Di-4-methylbenzyltin dichloride has been synthesized via the reaction of the tin powder with the 4-methylbenzyl chloride in the hydrous toluene. Two substituted benzyltin complexes has been synthesized via the reaction of the 2-oxo-propionic acid aroyl hydrazone with the di-4-methylbenzyltin dichloride. The complexes 1 and 2 have been characterized by IR, ¹H NMR, ¹³ NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines(MCF-7, HepG2, NCI-H460) and human cell line(HL-7702). Two complexes exhibited strong antitumor activity, moreover, 2 was less toxic than 1. The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe. The interaction of 1 with calf thymus DNA were intercalation and electrostatic attraction, however, that of 2 was only intercalation. CCDC:1487539, 1; 1053263, 2.
- organotin complex;hydrazone;synthesis;crystal structure;biological activity
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