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Citation: GAO Chuan-Zhu, CHEN Ji, WANG Tian-Shuai, ZHANG Yan, QIAN Yun-Xu, YANG Bo, GOU Shao-Hua, DONG Peng, ZHANG Ying-Jie. Synthesis and Antitumor Activity of Dinuclear Platinum Complexes with (1iR, 1iiR, 2iR, 2iiR)-Ni, Nii-(1, 3-Phenylenebis(methylene))dicyclohexane-1, 2-diamie as the Ligan[J]. Chinese Journal of Inorganic Chemistry, ;2015, (11): 2188-2196. doi: 10.11862/CJIC.2015.277 shu

Synthesis and Antitumor Activity of Dinuclear Platinum Complexes with (1iR, 1iiR, 2iR, 2iiR)-Ni, Nii-(1, 3-Phenylenebis(methylene))dicyclohexane-1, 2-diamie as the Ligan

  • 1.

    1 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;

  • 2.

    2 Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;

  • 3.

    3 Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650504, China

  • Corresponding author: GAO Chuan-Zhu,  ZHANG Ying-Jie, 
  • Received Date: 10 June 2015
    Available Online: 23 August 2015

    Fund Project: 国家自然科学基金(No.21361014,21302074) (No.21361014,21302074)国家自然科学基金(No.21362016) (No.21362016)教育部博士点基金(No.20125314120007)资助项目。 (No.20125314120007)

  • Seven diculear platinum complexes with the new chiral ligand, (1iR,1iiR,2iR,2iiR)-Ni, Nii-(1,3-phenylenebis(methylene))dicyclohexane-1,2-diamine (HL), were designed, synthesized and spectrally characterized by IR, 1H NMR, 13C NMR, ESI-MS and microanalyses. The cytotoxicities of targeted dinuclear platinum compounds against human HepG-2, A549, HCT-116 and MCF-7 cell lines were evaluated by MTT assay. Results indicated that all compounds exhibited positive activity to HepG-2, A549 and HCT-116 cell lines, but none of them showed activity to MCF-7 cell line. Among them, compound P7, owing to 3-hydroxycyclobutane-1,1-dicarboxylate as the leaving group, gave better antitumor activity than carboplatin against HepG-2 and A549 cell lines, and close cytotoxicity to oxaliplatin against HCT-116 cell line.
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