Citation: CHEN Xiang, CHAO Hui, JI Liang-Nian. New Trends of Ruthenium Complexes as Inhibitors Targeting Topoisomerase and Telomerase[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(9): 1667-1677. doi: 10.11862/CJIC.2015.241
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The anti-tumor study of metal complexes, especially the platinum-base drugs, has achieved remarkable success but still facing several problems such as drugs resistance and side effects. Recently, ruthenium complexes attract many scientists' interests with their brand new application of anti-tumor drugs. In the series of non-platinum drugs, ruthenium complexes are regarded as one of the most potential anti-tumor drugs for the reason not merely the metal ruthenium and its complexes exhibit low toxicity but also they can be efficiently absorbed and excreted for human body. Herein, the study of the follow-up inhibition towards nucleus enzymes induced by the binding between ruthenium complexes and DNA was expatiated, introducing the advance anti-tumor applications of ruthenium complexes in new perspectives.
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