Citation: SUN Jing-Hua, ZHANG Wei, TAN Cai-Ping, JI Liang-Nian, MAO Zong-Wan. Synthesis of β-Cyclodextrin Functionalized Fluorescent Gold Nanoclusters for Cellular Imaging[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(9): 1913-1918. doi: 10.11862/CJIC.2015.239
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A new kind of highly fluorescent AuNCs functionalized with β-cyclodextrin (CD) was prepared by using one-pot aqueous reduction of gold precursor. Aqueous dispersion of these red AuNCs exhibits good long-term colloidal stability as well as fluorescent stability. The average diameter of AuNCs-CD is (1.40±0.32) nm as determined by transmission electron microscopy (TEM). Confocal microscopic observation shows that AuNCs-CD can penetrate into cells and mainly localize within the cytoplasm. In vitro cytotoxicity assay indicates that the AuNCs-CD displays very low cytotoxicity against human lung adenocarcinoma A549 cells. Cyclodextrin modification is expected to make AuNCs more versatile for encapsulation of hydrophobic drugs and functionalization with targeting moieties, which will broaden the potential of AuNCs-CD for biomedical applications.
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-
[1]
[1] Choi S, Dickson R M, Yu J. Chem. Soc. Rev., 2012,41(5):1867-1891
-
[2]
[2] Tanaka S I, Miyazaki J, Tiwari D K, et al. Angew. Chem. Int. Ed., 2011,123(2):451-455
-
[3]
[3] Yuan X, Luo Z, Zhang Q, et al. ACS Nano, 2011,5(11):8800-8808
-
[4]
[4] Zhang H, Huang X, Li L, et al. Chem. Commun., 2011,48(4):567-569
-
[5]
[5] Shang L, Dong S, Nienhaus G U. Nano Today, 2011,6(4):401-418
-
[6]
[6] Shang L, Azadfar N, Stockmar F, et al. Small, 2011,7(18):2614-2620
-
[7]
[7] Wu Z, Suhan J, Jin R. J. Mater. Chem., 2009,19(5):622-626
-
[8]
[8] Xie J, Zheng Y, Ying J Y. J. Am. Chem. Soc., 2009,131(3):888-889
-
[9]
[9] Biju V. Chem. Soc. Rev., 2014,43(3):744-764
-
[10]
[10] Huang C C, Liao H Y, Shiang Y C, et al. J. Mater. Chem., 2009,19(6):755-759
-
[11]
[11] Shang L, Stockmar F, Azadfar N, et al. Angew. Chem. Int. Ed., 2013,52(42):11154-11157
-
[12]
[12] Chen T, Hu Y, Cen Y, et al. J. Am. Chem. Soc., 2013,135(31):11595-11602
-
[13]
[13] Palmal S, Basiruddin S, Maity A R, et al. Chem. Eur. J., 2013,19(3):943-949
-
[14]
[14] Sun J, Jin Y. J. Mater. Chem. C, 2014,2(38):8000-8011
-
[15]
[15] Schmid G, Fenske D. Phil. Trans. R. Soc. A, 2010,368(1915):1207-1210
-
[16]
[16] Li J J, Wang Y A, Guo W, et al. J. Am. Chem. Soc., 2003, 125(41):12567-12575
-
[17]
[17] Stewart M H, Susumu K, Mei B C, et al. J. Am. Chem. Soc., 2010,132(28):9804-9813
-
[18]
[18] Liu C L, Wu H T, Hsiao Y H, et al. Angew. Chem. Int. Ed., 2011,50(31):7056-7560
-
[19]
[19] Polavarapu L, Manna M, Xu Q H. Nanoscale, 2011,3(2):429-434
-
[20]
[20] Chen G, Jiang M. Chem. Soc. Rev., 2011,40(5):2254-2266
-
[21]
[21] Hu Q D, Tang G P, Chu P K. Acc. Chem. Res., 2014,47(7):2017-2025
-
[22]
[22] Lai W F. Biomaterials, 2014,35(1):401-411
-
[23]
[23] Li J M, Wang Y Y, Zhao M X, et al. Biomaterials, 2012,33(9):2780-2790
-
[24]
[24] Zhao M X, Li J M, Du L, et al. Chem. Eur. J., 2011,17(18):5171-5179
-
[25]
[25] Shen J, Kim H C, Su H, et al. Theranostics, 2014,4(5):487-489
-
[26]
[26] Park C, Youn H, Kim H, et al. J. Mater. Chem., 2009,19(16):2310-2315
-
[27]
[27] He H, Chen S, Zhou J, et al. Biomaterials, 2013,34(21):5344-5358
-
[28]
[28] Petter R C, Salek J S, Sikorski C T, et al. J. Am. Chem. Soc., 1990,112(10):3860-3868
-
[29]
[29] May B, Kean S, Easton C, et al. J. Chem. Soc., Perkin Trans. 1, 1997(21):3157-3160
-
[30]
[30] Liu Y, You C C, Wada T, et al. Tetrahedron Lett., 2000,41(35):6869-6873
-
[31]
[31] Aldeek F, Muhammed M A H, Palui G, et al. ACS Nano, 2013,7(3):2509-2521
-
[32]
[32] Negishi Y, Nobusada K, Tsukuda T. J. Am. Chem. Soc., 2005,127(14):5261-5270
-
[33]
[33] Muhammed M A H, Verma P K, Pal S K, et al. Chem. Eur. J., 2009,15(39):10110-10120
-
[34]
[34] Yau S H, Varnavski O, Goodson T. Acc. Chem. Res., 2013, 46(7):1506-1516
-
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