Citation: HAN Xue-Feng, CAI Hong-Xin, JIA Lei, WU Wei-Na, ZHANG Xin, XU Jun, ZHANG Zhao-Po, WANG Yuan. Syntheses, Characterizations and Antitumor Activities of Two Copper(Ⅱ) Complexes with an Acylhydrazone Ligand Bearing Pyrrole Unit[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(7): 1453-1459. doi: 10.11862/CJIC.2015.188
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Two interesting copper(Ⅱ) complexes,[Cu(H2L)2(THF)] (1) and[Cu2(L)Cl(CH3OH)]·H2O (2) based on H3L {ethyl 5-[(2-hydroxyl-4-methylbenzoyl)amino-iminomethyl]-3,4-dimethyl-pyrrole-2-carboxylate} were synthesized and characterized by X-ray diffraction analyses. The results show that in complex 1, the copper(Ⅱ) ion is surrounded by two mono-deprotonated acylhydrazone ligands with NO donor sets and one THF molecule, and thus possesses a distorted square pyramidal geometry. However, in binuclear complex 2, the acylhydrazone ligand is tri-deprotonated and bridges two copper(Ⅱ) ions with square-planar coordination geometry through NO and N2O2 atom sets, respectively. Both complexes have excellent antitumor activities towards A549, ECA109 and SGC7901 cancer cells.
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