Citation: HE Miao, JIAO Qing-Zhu, CHEN Xiang-Fei, LI Jian, CHEN Jie, SHENG Gui-Hua, YOU Zhong-Lu. Syntheses, Characterization, Crystal Structures and Insulin-Like Activity of Vanadium(Ⅴ) Complexes with Aroylhydrazone and Maltol Mixed-Ligands[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(8): 1590-1596. doi: 10.11862/CJIC.2015.174
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Two vanadium(Ⅴ) complexes, [VOLL1] (1) and [VOLL2] (1) (L=N'-(3,5-dibromo-2-hydroxybenzylidene)-3-methylbenzohydrazide, L1=methylmaltol, L2=ethylmaltol), have been prepared. The complexes have been characte-rized by physico-chemical methods and single crystal X-ray determination. The V atom in each complex is coordinated by three donor atoms of L, two donor atoms of L1 or L2, and one oxo group, forming octahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mices for two weeks. The biological activity results show that the complexes at doses of 10.0 and 20.0 mgV·kg-1, can significantly decrease the blood glucose level in alloxan-diabetic mices, but the blood glucose level in the treated normal mices was not altered. CCDC: 1059791, 1; 1059793, 2.
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