Citation: SUN Jing, SONG Xing-Dong, CHEN Wen-Xiu, ZHAO Xuan-Hao, CHEN Jia-Xi, JIA Zhen-Bin, HAO Hong-Qing. Synthesis, Crystal Structure and Interactions with G-Quadruplex Structures of [Ru(dpq)2L]4+[J]. Chinese Journal of Inorganic Chemistry, ;2015, (5): 865-872. doi: 10.11862/CJIC.2015.142
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Based on cis-[Ru(dpq)2Cl2]·2H2O (dpq=dipyrido[3,2-d:2',3'-f]quinoxaline) and 5,5'-di(1-(triethylamm-onio)methyl)-2,2'-dipyridyl cation ligand (L), the complex [Ru(dpq)2L](PF6)4 was synthesized and structurally characterized. The interactions of the complex with different G-quadruplexes were investigated. FRET melting assay proved that the complex bonds more strongly to h-telo than to promoters, such as c-myc and bcl2. CD studies show that Ru(Ⅱ) complex can induce the formation of parallel G-quadruplex of h-telo in the absence of Na+ or K+. Results of absorption and emission titration indicated that the complex has a higher DNA affinity with h-telo in K+ buffer than in Na+ buffer.
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