Citation: YE Yu-Ting, NIU Fang, SUN Ying, QU Dan, ZHAO Xin-Lu, WANG Jia, XIAN Dong-Mei, Hauser Jürg, YOU Zhong-Lu. N'-(2-Hydroxy-5-methoxybenzylidene)-4-dimethylaminobenzohydrazide and Its Oxovanadium(Ⅴ) Complex: Syntheses, Crystal Structures, and Urease Inhibitory Activity[J]. Chinese Journal of Inorganic Chemistry, ;2015, (5): 1019-1026. doi: 10.11862/CJIC.2015.135
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Abenzohydrazone compound N'-(2-hydroxy-5-methoxybenzylidene)-4-dimethylaminobenzohydrazide (H2L) was prepared. Reaction of H2L and acetylhydroxamic acid (HAHA) with VO(acac)2 in methanol gave complex [VOL(AHA)]. Both H2L and the oxovanadium complex were characterized by elemental analysis, IR and UV-Vis spectra, and single crystal X-ray diffraction. The benzohydrazone ligand, in its dianionic form, coordinates to Vatom through the phenolate oxygen, imino nitrogen and enolate oxygen. The acetohydroxamic acid coordintes to Vatom through the carbonyl oxygen and deprotonated hydroxyl oxygen. The Vatom is in octahedral coordination. H2L, HAHAand the oxovanadium(Ⅴ) complex were tested for their urease inhibitory activities. The inhibition rate at concentration of 100 μmol·L-1 on Helicobacter pylori urease is 63% for the oxovanadium complex. The IC50 value for the complex is 45 μmol·L-1. Molecular docking study was performed to study the inhibition.
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