Citation: YE Yu-Ting, NIU Fang, SUN Ying, QU Dan, ZHAO Xin-Lu, WANG Jia, XIAN Dong-Mei, Hauser Jürg, YOU Zhong-Lu. N'-(2-Hydroxy-5-methoxybenzylidene)-4-dimethylaminobenzohydrazide and Its Oxovanadium(Ⅴ) Complex: Syntheses, Crystal Structures, and Urease Inhibitory Activity[J]. Chinese Journal of Inorganic Chemistry, ;2015, (5): 1019-1026. doi: 10.11862/CJIC.2015.135 shu

N'-(2-Hydroxy-5-methoxybenzylidene)-4-dimethylaminobenzohydrazide and Its Oxovanadium(Ⅴ) Complex: Syntheses, Crystal Structures, and Urease Inhibitory Activity

YE Yu-Ting ¹ ,
NIU Fang ¹ ,
SUN Ying ¹ ,
QU Dan ¹ ,
ZHAO Xin-Lu ¹ ,
WANG Jia ¹ ,
XIAN Dong-Mei ¹ ,
Hauser Jürg ³ ,
YOU Zhong-Lu ^1,2,,

1.
1 Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China;
2.
2 State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China;
3.
3 Departement of Chemistry and Biochemistry, University of Bern, Bern 3012, Switzerland

Corresponding author: YOU Zhong-Lu,
Received Date: 3 December 2014
Available Online: 19 March 2015
Fund Project: 辽宁省高校优秀青年人才支持计划(No.LR2014032)资助项目。 (No.LR2014032)

Abenzohydrazone compound N'-(2-hydroxy-5-methoxybenzylidene)-4-dimethylaminobenzohydrazide (H₂L) was prepared. Reaction of H₂L and acetylhydroxamic acid (HAHA) with VO(acac)₂ in methanol gave complex [VOL(AHA)]. Both H₂L and the oxovanadium complex were characterized by elemental analysis, IR and UV-Vis spectra, and single crystal X-ray diffraction. The benzohydrazone ligand, in its dianionic form, coordinates to Vatom through the phenolate oxygen, imino nitrogen and enolate oxygen. The acetohydroxamic acid coordintes to Vatom through the carbonyl oxygen and deprotonated hydroxyl oxygen. The Vatom is in octahedral coordination. H₂L, HAHAand the oxovanadium(Ⅴ) complex were tested for their urease inhibitory activities. The inhibition rate at concentration of 100 μmol·L^-1 on Helicobacter pylori urease is 63% for the oxovanadium complex. The IC₅₀ value for the complex is 45 μmol·L^-1. Molecular docking study was performed to study the inhibition.
- benzohydrazone;oxovanadium complex;crystal structure;urease inhibition
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