Citation: DU Fang-Yuan, LI Shi-Kun, LIN Qiu-Yue, WEI Qiong, TANG Ning-Ning. Structures, Interaction with DNA and BSA and Antiproliferative Activities of Ni(Ⅱ) and Cd(Ⅱ) Complexes Based on Demethylcantharate and Imidazole[J]. Chinese Journal of Inorganic Chemistry, ;2015, (4): 813-823. doi: 10.11862/CJIC.2015.113 shu

Structures, Interaction with DNA and BSA and Antiproliferative Activities of Ni(Ⅱ) and Cd(Ⅱ) Complexes Based on Demethylcantharate and Imidazole

1.
1 Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Zhejiang Normal University, Jinhua, Zhejiang 321004, China;
2.
2 College of Chemical and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China

Corresponding author: LIN Qiu-Yue,
Received Date: 20 October 2014
Available Online: 13 January 2015
Fund Project: 国家自然科学基金(No．)资助项目 (No．)

Two mixed-ligand complexes [Ni(IM)(DCA)(H₂O)₂]·2H₂O (1) and [Cd₂(IM)₄(DCA)₂]·2H₂O (2) (DCA=demethylcantharate, 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate, C₈H₈O₅; IM=imidazole, C₃H₄N₂) were synthesized and characterized by elemental analysis, infrared spectra, thermogravimetric analysis, and X-ray diffraction. Complex 1 was a mononuclear molecule, with Ni(Ⅱ) ion six-coordinated by one nitrogen atom from imidazole, three oxygen atoms from DCA and two water molecules. The complex 1 crystallized in the monoclinic crystal system with P2₁/m. Complex 2 was a binuclear molecule, each Cd(Ⅱ) ion was six-coordinated by two nitrogen atoms from two imidazole, one ether oxygen atom and three oxygen atoms of carboxyl groups from DCA. The complex 2 crystallized in the triclinic crystal system with P1 space group. The DNA binding properties of the complexes were investigated by electronic absorption spectra, fluorescence spectra and viscosity measurements. These two complexes could bind to DNA with moderate intensity via partial intercalation. The binding constants K_b were 5.51×10³ (1) and 1.01×10³ L·mol^-1 (2) at 298 K, respectively. Meanwhile, the binding intensity of complex with bovine serum albumin (BSA) is high, with binding constants K_A equal to 1.91×10⁵ (1) and 6.17×10⁵ L·mol^-1 (2), respectively. Experimental results showed that complexes and BSA formed a 1:1 compound with conforma-tional changes in BSA. The antiproliferative activities of the complex (1) against human hepatoma cells (SMMC7721) lines and human breast cancer cells (MCF-7) lines were tested with MTT assay in vitro. The results showed that the inhibition effect had selectivity against cancer cells after forming complexes. The antiproliferative activities of the complex (IC₅₀=(86.8±6.1) μmol·L^-1) against the human hepatoma cells lines was more intense than Na₂(DCA) (IC₅₀=(152.8±15.6) μmol·L^-1), which suggests potential application in anti-cancer drug development. CCDC: 822330, 1; 822328, 2.
- imidazole;disodium demethylcantharate;nickel complex;cadmium complex;interaction with DNA and BSA; antiproliferative activity
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