Citation: KUANG Dai-Zhi, YU Jiang-Xi, FENG Yong-Lan, ZHANG Fu-Xing, JIANG Wu-Jiu, ZHU Xiao-Ming. Syntheses, Structures, Anti-tumor Activity of Tri(n-butyl)tin Carboxylates with Hydrogen-Bonded Network[J]. Chinese Journal of Inorganic Chemistry, ;2015, (6): 1112-1118. doi: 10.11862/CJIC.2015.067 shu

Syntheses, Structures, Anti-tumor Activity of Tri(n-butyl)tin Carboxylates with Hydrogen-Bonded Network

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Key Laboratory of Functional Organometallic Materials of College of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: KUANG Dai-Zhi,
Received Date: 14 November 2014
Available Online: 15 December 2014
Fund Project: 湖南省自然科学基金(No.13JJ3112) (No.13JJ3112)湖南省科技计划(No.2014NK3086) (No.2014NK3086)湖南省高校创新平台开放基金(No.13K105,14K014) (No.13K105,14K014)重点实验室开放基金(No.13K01,GN14K01) (No.13K01,GN14K01)湖南省“十二五”重点建设学科(材料物理与化学) (材料物理与化学)衡阳师范学院协同创新中心培育项目(No.12XT02) (No.12XT02)青年骨干教师培养计划(2012)资助项目。 (2012)

Two tri(n-butyl)tin carboxylates (n-Bu)₃SnO₂CR(H₂O) (R: C(OH)Ph₂ (1), C₅NH₃Cl (2)) were synthesized by the reactions of bis[tri(n-butyl)tin] oxide with benzilic acid and 2-chloronicotinic acid under microwave irradia-tion, respectively. Their structures were characterized by IR, ¹H and ¹³C NMR, elemental analysis and X-ray single crystal diffraction. Both of the complexes belong to orthorhombic system, but their space groups are different. One is Pbca and the other is P2₁2₁2₁. For each of them, the central tin atom is aberrant trigonal bipyramid with five-coordination. In their crystal structures, there are multi-hydrogen bonds, resulting in the formation of a 2D structure of 1 and a 3D supermolecular network of 2. The preliminary tests showed that both of which displayed strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460, and especially for the later three, the complexes were much stronger than carboplatin, but the activity order was 1>2.
- tri(n-butyl)tin carboxylate;crystal structure;supermolecular network;anti-tumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142