Citation: JIAO Yuan-Hong, ZHANG Qian, JIANG Yu-Feng, ZHANG Wan-Ju. A Benzothiazole-Derived Fluorescent Probe for Detecting Hg(Ⅱ) in Live Cells[J]. Chinese Journal of Inorganic Chemistry, ;2015, (2): 361-368. doi: 10.11862/CJIC.2015.019 shu

A Benzothiazole-Derived Fluorescent Probe for Detecting Hg(Ⅱ) in Live Cells

1.
1. College of Chemistry and Chemical Engineering, Hubei Polytechnic University, Huangshi, Hubei 435003, China;
2.
2. Hubei Key Laboratory for Processing and Application of Catalytic Materials, Huanggang Normal University, Huanggang, Hubei 438000, China;
3.
3. Hubei Key Laboratory of Mine Environmental Pollution Control & Remediation, Hubei Polytechnic University, Huangshi, Hubei 435003, China

Corresponding author: ZHANG Wan-Ju,
Received Date: 29 August 2014
Available Online: 25 October 2014
Fund Project: 湖北省教育厅B类项目(No.B20114404) (No.B20114404)矿区环境污染控制与修复湖北省重点实验室开放基金项目(No.2012103) (No.2012103)湖北省教育厅青年人才资助项目(No.Q20132901) (No.Q20132901)

Abenzothiazole-derived fluorescent probe (YH1) has been synthesized and structurally characterized, and its response to different metal ions has been investigated by spectrometry. The results showed that YH1 exhibited good sensitivity and selectivity to Hg²⁺. Its interaction with Hg²⁺ caused the color of its solution changed from blue to colorless under UVirradiation. There was a good linear relationship between the fluorescence intensity of YH1 and the concentration of Hg²⁺ in the range of 1.4 μmol·L^-1 to 8.8 μmol·L^-1, and its detection limit for Hg²⁺ was 0.56 μmol·L^-1. Moreover, the cell membrane penetration of YH1 had low cytotoxicity, and it can be applied to image intracellular Hg²⁺ in living HeLa cells. CCDC: 978108.
- crystal structure;Hg²⁺;fluorescent probe;benzothiazole;fluorescent imaging
1. [1]
  [1] Nolan E M, Lipard S J. Chem. Rev., 2008,108:3443-3480
2. [2]
  [2] Guo Z Q, Park S, Yoon J, et al. Chem. Soc. Rev., 2014,43: 16-29
3. [3]
  [3] Li X H, Gao X H, Shi W, et al. Chem. Rev., 2014,114:590-659
4. [4]
  [4] Guo Z Q, Zhu W H, Zhu M M, et al. Chem. Eur. J., 2010, 16:14424-14432
5. [5]
  [5] Tong S, Zhang L, Bing L, et al. Sensor Actuators B: Chem., 2014,203:157-164
6. [6]
  [6] Nolan E M, Racine M E, Lippard S J. Inorg. Chem., 2006, 45:2742-2749
7. [7]
  [7] Shi H F, Liu S J, Sun H B, et al. Chem. Eur. J., 2010,16: 12158-12167
8. [8]
  [8] Tsukamoto K, Shinohara Y, Iwasakia S, et al. Chem. Commun., 2011,47:5073-5075
9. [9]
  [9] Zhao Q, Liu S J, Li F Y, et al. Dalton Trans., 2008:3836-3840
10. [10]
  [10] Tayade K, Bondhopadhyay B, Basu A, et al. Talanta, 2014, 122:16-22
11. [11]
  [11] Sun H B, Liu S J, Ma T C, et al. New J. Chem., 2011,35: 1194-1197
12. [12]
  [12] Wanichacheva N, Watpathomsub S, Lee V S, et al. Molecules, 2010,15:1798-1810
13. [13]
  [13] Zhao Q, Cao T Y, Li F Y, et al. Organometallics, 2007,26: 2077-2081
14. [14]
  [14] Jeong H J, Li Y, Hyun M H. Bull. Korean Chem. Soc., 2011,32:2809-2812
15. [15]
  [15] Tsukamoto K, Shinohara Y, Iwasakia S, et al. Chem. Commun., 2011,47:5073-5075
16. [16]
  [16] Kim S H, Kim J S, Park S M, et al. Org. Lett., 2006,8:371-374
17. [17]
  [17] Kim S H, Youn N J, Park J Y, et al. Bull. Korean Chem. Soc., 2006,27:1553-1156
18. [18]
  [18] Sakamoto H, Ishikawa J, Nakao S, et al. Chem. Commun., 2000:2395-2396
19. [19]
  [19] Santra M, Roy B, Ahn K H. Org. Lett., 2011,13:3422-3425
20. [20]
  [20] Sun W, Li W H, Li J, et al. Tetrahedron Lett., 2012,53: 2332-2335
21. [21]
  [21] ZHANG Yong(张勇), WANG Qiang(王强), LI Wei(李伟), et al. Chin. J. Org. Chem.(有机化学), 2014,34(2):403-408
22. [22]
  [22] Sheldrick G M. SHELXS-97, Program for the Solution of Crystal Structures, University of Göttingen, Germany, 1997.
23. [23]
  [23] Sheldrick G M. SHELXL-97, Program for the Refinement of Crystal Structures, University of Göttingen, Germany, 1997.
24. [24]
  [24] Shortreed M, Kopelman R, Kuhn M, et al. Anal. Chem., 1996,68:1414-1418
25. [25]
  [25] Benesi H A, Hildebrand J H. J. Am. Chem. Soc., 1949,71: 2703-2707
26. [26]
  [26] Jeong H J, Li Y, Hyun M H. Bull. Korean Chem. Soc., 2011,32:2809-2812
1. [1]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
2. [2]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
3. [3]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
4. [4]
  Xiaoling LUO , Pintian ZOU , Xiaoyan WANG , Zheng LIU , Xiangfei KONG , Qun TANG , Sheng WANG . Synthesis, crystal structures, and properties of lanthanide metal-organic frameworks based on 2, 5-dibromoterephthalic acid ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1143-1150. doi: 10.11862/CJIC.20230271
5. [5]
  Yingchun ZHANG , Yiwei SHI , Ruijie YANG , Xin WANG , Zhiguo SONG , Min WANG . Dual ligands manganese complexes based on benzene sulfonic acid and 2, 2′-bipyridine: Structure and catalytic properties and mechanism in Mannich reaction. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1501-1510. doi: 10.11862/CJIC.20240078
6. [6]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
7. [7]
  Xinting XIONG , Zhiqiang XIONG , Panlei XIAO , Xuliang NIE , Xiuying SONG , Xiuguang YI . Synthesis, crystal structures, Hirshfeld surface analysis, and antifungal activity of two complexes Na(Ⅰ)/Cd(Ⅱ) assembled by 5-bromo-2-hydroxybenzoic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1661-1670. doi: 10.11862/CJIC.20240145
8. [8]
  Jingjing QING , Fan HE , Zhihui LIU , Shuaipeng HOU , Ya LIU , Yifan JIANG , Mengting TAN , Lifang HE , Fuxing ZHANG , Xiaoming ZHU . Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1301-1308. doi: 10.11862/CJIC.20240003
9. [9]
  Zhaoyang WANG , Chun YANG , Yaoyao Song , Na HAN , Xiaomeng LIU , Qinglun WANG . Lanthanide(Ⅲ) complexes derived from 4′-(2-pyridyl)-2, 2′∶6′, 2″-terpyridine: Crystal structures, fluorescent and magnetic properties. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1442-1451. doi: 10.11862/CJIC.20240114
10. [10]
  Meirong HAN , Xiaoyang WEI , Sisi FENG , Yuting BAI . A zinc-based metal-organic framework for fluorescence detection of trace Cu²⁺. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1603-1614. doi: 10.11862/CJIC.20240150
11. [11]
  Jiakun BAI , Ting XU , Lu ZHANG , Jiang PENG , Yuqiang LI , Junhui JIA . A red-emitting fluorescent probe with a large Stokes shift for selective detection of hypochlorous acid. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1095-1104. doi: 10.11862/CJIC.20240002
12. [12]
  Yonghui ZHOU , Rujun HUANG , Dongchao YAO , Aiwei ZHANG , Yuhang SUN , Zhujun CHEN , Baisong ZHU , Youxuan ZHENG . Synthesis and photoelectric properties of fluorescence materials with electron donor-acceptor structures based on quinoxaline and pyridinopyrazine, carbazole, and diphenylamine derivatives. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 701-712. doi: 10.11862/CJIC.20230373
13. [13]
  Peiran ZHAO , Yuqian LIU , Cheng HE , Chunying DUAN . A functionalized Eu³⁺ metal-organic framework for selective fluorescent detection of pyrene. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 713-724. doi: 10.11862/CJIC.20230355
14. [14]
  Yue WANG , Zhizhi GU , Jingyi DONG , Jie ZHU , Cunguang LIU , Guohan LI , Meichen LU , Jian HAN , Shengnan CAO , Wei WANG . Effects of kelp-derived carbon dots on embryonic development of zebrafish. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1209-1217. doi: 10.11862/CJIC.20230423
15. [15]
  Huan ZHANG , Jijiang WANG , Guang FAN , Long TANG , Erlin YUE , Chao BAI , Xiao WANG , Yuqi ZHANG . A highly stable cadmium(Ⅱ) metal-organic framework for detecting tetracycline and p-nitrophenol. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 646-654. doi: 10.11862/CJIC.20230291
16. [16]
  Ruikui YAN , Xiaoli CHEN , Miao CAI , Jing REN , Huali CUI , Hua YANG , Jijiang WANG . Design, synthesis, and fluorescence sensing performance of highly sensitive and multi-response lanthanide metal-organic frameworks. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 834-848. doi: 10.11862/CJIC.20230301
17. [17]
  Xiaoxia WANG , Ya'nan GUO , Feng SU , Chun HAN , Long SUN . Synthesis, structure, and electrocatalytic oxygen reduction reaction properties of metal antimony-based chalcogenide clusters. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1201-1208. doi: 10.11862/CJIC.20230478
18. [18]
  Lu LIU , Huijie WANG , Haitong WANG , Ying LI . Crystal structure of a two-dimensional Cd(Ⅱ) complex and its fluorescence recognition of p-nitrophenol, tetracycline, 2, 6-dichloro-4-nitroaniline. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1180-1188. doi: 10.11862/CJIC.20230489
19. [19]
  Kaimin WANG , Xiong GU , Na DENG , Hongmei YU , Yanqin YE , Yulu MA . Synthesis, structure, fluorescence properties, and Hirshfeld surface analysis of three Zn(Ⅱ)/Cu(Ⅱ) complexes based on 5-(dimethylamino) isophthalic acid. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1397-1408. doi: 10.11862/CJIC.20240009
20. [20]
  Shuyan ZHAO . Field-induced Co^Ⅱ single-ion magnet with pentagonal bipyramidal configuration. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1583-1591. doi: 10.11862/CJIC.20240231

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(101)
HTML views(0)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142