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Citation: WANG Li-Na, LI Shuang, HUANG Fu-Ping, YU Qing, BIAN He-Dong, CHEN Zhen-Feng, LIANG Hong. Conformational Changes of Human Serum Albumin by Plumbagin in Presence of Cu2+ or Mn2+[J]. Chinese Journal of Inorganic Chemistry, ;2014, 30(5): 1151-1159. doi: 10.11862/CJIC.2014.027 shu

Conformational Changes of Human Serum Albumin by Plumbagin in Presence of Cu2+ or Mn2+

  • 1.

    School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, Guangxi 541004, China

  • Received Date: 27 April 2013
    Available Online: 23 July 2013

    Fund Project: 国家自然科学基金(No.21361003，21061002)；教育部留学回国人员科研启动基金；广西自然科学基金(Nos.2010GXNSFF013001，2011GXNSFC018009)；药用资源化学与药物分子工程教育部重点实验室主任基金(CMEMR2011-20，CMEMR2012-A02)；广西医药产业人才小高地项目(No.1201)资助。 (No.21361003，21061002)；教育部留学回国人员科研启动基金；广西自然科学基金(Nos.2010GXNSFF013001，2011GXNSFC018009)；药用资源化学与药物分子工程教育部重点实验室主任基金(CMEMR2011-20，CMEMR2012-A02)；广西医药产业人才小高地项目(No.1201)

  • Circular dichroism (CD) and Raman spectroscopy were employed to investigate the binding of plumbagin (PLU) to human serum albumin (HSA) in the presence of Cu2+ or Mn2+. The results indicate that PLU changes the secondary structure of HSA and reduces the α-helix content. The binding of PLUalso causes the conformational changes of disulfide bridges and the microenvironment of Tyr, Trp residues. In the presence of the metal ion (Cu2+or Mn2+), the above changes are gradually strengthened.
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