Citation: Liu-Liang Mao, Yunyun Liu, Jie-Ping Wan. An update on the advances in chromone and the derivatives synthesis based on the key chromone annulation of o-hydroxyaryl enaminones[J]. Chinese Chemical Letters, ;2025, 36(7): 110784. doi: 10.1016/j.cclet.2024.110784 shu

An update on the advances in chromone and the derivatives synthesis based on the key chromone annulation of o-hydroxyaryl enaminones

a.
College of Chemistry and Environment Science, Shangrao Normal University, Shangrao 334001, China
b.
Institute of Flow Chemistry and Engineering, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China

wanjieping@jxnu.edu.cn

Received Date: 27 September 2024
Revised Date: 9 December 2024
Accepted Date: 19 December 2024
Available Online: 19 December 2024

Figures(48)

Chromones serve as versatile heterocyclic scaffolds and are common core structural units in a variety of natural products and bioactive organic molecules. This area of research, at the forefront of organic synthesis, has seen remarkable progress in recent years. Among the various synthetic methodologies for accessing chromone scaffolds, the tandem annulation of o-hydroxyaryl enaminones has emerged as a robust and practical strategy. This approach, through direct vinyl CH bond functionalization of o-hydroxyaryl enaminones, enables the construction of structurally diverse chromones (including 3-substituted chromones, 2-substituted chromones, and 2,3-disubstituted chromones) and their derivatives since mid-2019. In this review, we highlight recent advances in the synthesis of various types of chromones and their derivatives, achieved through tandem direct vinyl CH activation and chromone annulation of o-hydroxyaryl enaminones.
- o-Hydroxyaryl enaminone,
- Chromone,
- Structurally diversity,
- Annulation,
- Advances
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沈阳化工大学材料科学与工程学院沈阳 110142