Citation: Bingyang Lu, Dehui Wang, Junchang Guo, Yang Shen, Qian Feng, Jinlong Yang, Xiao Han, Huali Yu, Luohuizi Li, Jiaxin Liu, Jing Luo, Huan Liu, Zhongwei Zhang, Xu Deng. High-efficiency exudates drainage of anti-adhesion dressings for chronic wound[J]. Chinese Chemical Letters, ;2025, 36(4): 110601. doi: 10.1016/j.cclet.2024.110601 shu

High-efficiency exudates drainage of anti-adhesion dressings for chronic wound

Bingyang Lu ^a ,
Dehui Wang ^{a, *,} ,
Junchang Guo ^a ,
Yang Shen ^a ,
Qian Feng ^b ,
Jinlong Yang ^a ,
Xiao Han ^a ,
Huali Yu ^a ,
Luohuizi Li ^a ,
Jiaxin Liu ^a ,
Jing Luo ^{a, *,} ,
Huan Liu ^{b, *,} ,
Zhongwei Zhang ^{b, *,} ,
Xu Deng ^{a, c, *,}

a.
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, China
b.
Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
c.
Shenzhen Institute for Advanced Study, University of Electronic Science and Technology of China, Shenzhen 518110, China

wangdehui@uestc.edu.cn

luojing115@uestc.edu.cn

liuhuan881129@163.com

716461751@qq.com

dengxu@uestc.edu.cn

Received Date: 22 September 2024
Revised Date: 27 October 2024
Accepted Date: 31 October 2024
Available Online: 1 November 2024

Figures(4)

Secondary trauma, resulting in undesirable injury and bleeding during wound dressing treatment, which will cause the treatment of chronic wounds ineffective. The medical cotton gauzes often bring strong adhesion due to the exudates absorbed and clots formed. Conversely, the easily detachable wound dressings neglect the wound seepage management, rendering them ineffective in facing the complexities of chronic wounds. To address this challenge, we propose a novel draining anti-adhesion dressings (DAD) by constructing the hydrophilic microchannels array on the superhydrophobic dressing. The superhydrophobic areas facilitate stable wound fluid repellence leading to achieve the anti-adhesion (18.7% detachment energy of cotton) and the microchannel array ensures the transportation of excess exudates (>92%) by the capillary force. Notably, our dressing demonstrates a significant healing-promoting in a chronic wound model in rats. The development of such dressings holds promise for advancing wound care practices and addressing the unique challenges posed by chronic wounds, offering a valuable solution for improved clinical outcomes.
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