Citation: Hong-Tao Ji, Yu-Han Lu, Yan-Ting Liu, Yu-Lin Huang, Jiang-Feng Tian, Feng Liu, Yan-Yan Zeng, Hai-Yan Yang, Yong-Hong Zhang, Wei-Min He. Nd@C₃N₄-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines[J]. Chinese Chemical Letters, ;2025, 36(2): 110568. doi: 10.1016/j.cclet.2024.110568 shu

Nd@C₃N₄-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines

Hong-Tao Ji ^{a, b} ,
Yu-Han Lu ^b ,
Yan-Ting Liu ^a ,
Yu-Lin Huang ^a ,
Jiang-Feng Tian ^b ,
Feng Liu ^a ,
Yan-Yan Zeng ^b ,
Hai-Yan Yang ^c ,
Yong-Hong Zhang ^{a, *,} ,
Wei-Min He ^{b, *,}

a.
Department of Ophthalmology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
b.
School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
c.
Department of Lung Cancer and Gastroenterology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China

2020030018@usc.edu.cn

weiminhe@usc.edu.cn

Received Date: 12 September 2024
Revised Date: 16 October 2024
Accepted Date: 18 October 2024
Available Online: 19 October 2024

Figures(7)

The first example of Nd@C₃N₄-photoredox/chlorine dual catalyzed alkylation with unactivated alkanes as the alkyl sources has been developed, which allows for the synthesis of various 4-alkylated cyclic sulfonyl ketimines. In this process, chlorine functions as both a redox and hydrogen atom transfer catalyst. The synergism of the reversible Nd²⁺/Nd³⁺ and Cl^¯/Cl˙ redox pairs significantly enhances overall photocatalytic efficiency. The in vitro anticancer activity of 4-alkylated products was evaluated by using the CCK8 assay against both human choroidal melanoma (MUM-2B) and lung cancer (A549) cell. Compound 3da showed approximately triple the potency of 5-fluorouracil.
- Dual catalysis,
- Semiconductor,
- Chlorine,
- Redox catalyst,
- Hydrogen atom transfer
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Nd@C3N4-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines

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通讯作者: 陈斌, bchen63@163.com

Nd@C₃N₄-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines