Citation: Ju Wang, Yongbing Sun, Lingbang Meng, Jianfang Feng, Meng Cheng, Liangxing Tu. Intestinal transporters and oral absorption enhancing strategies based on these transporters[J]. Chinese Chemical Letters, ;2025, 36(5): 110529. doi: 10.1016/j.cclet.2024.110529 shu

Intestinal transporters and oral absorption enhancing strategies based on these transporters

Ju Wang ^{a, 1} ,
Yongbing Sun ^{a, 1} ,
Lingbang Meng ^a ,
Jianfang Feng ^{a, b} ,
Meng Cheng ^{a, *,} ,
Liangxing Tu ^{a, *,}

a.
Jiangxi University of Chinese Medicine, Nanchang 330006, China
b.
Guangxi University of Chinese Medicine, Nanning 530200, China

cmjxzyy@126.com

tufrankie@163.com

Received Date: 22 August 2024
Revised Date: 3 October 2024
Accepted Date: 8 October 2024
Available Online: 18 October 2024

Figures(8)

Utilizing transporter-mediated drug delivery to achieve effective oral absorption emerges as a promising strategy. Researchers have been concentrated on discovering solutions to the issues of low solubility and poor permeability of insoluble drugs, whereas, current reports have revealed that drug transporter proteins are abundantly expressed in the mucosa of intestinal epithelial cells, and that their mediated drug absorption effectively improved the bioavailability of orally administered drugs. There are two main categories based on the transporter mechanism, which include the family of ATP-binding cassette (ABC) transporters with efflux effects that reduce drug bioavailability and the family of solute carriers (SLC) transporters with uptake effects that promote drug absorption, respectively. Thus, we review studies of intestinal transporter-mediated delivery of drugs to enhance oral absorption, including the types of intestinal transporters, distribution characteristics, and strategies for enhancing oral absorption using transporter-mediated drug delivery systems are summarized, with the aim of providing important theoretical references for the development of intestinal-targeted delivery system.
- Intestinal transporter,
- Bioavailability,
- Oral delivery,
- Intestinal absorption,
- SLC transporters,
- ABC transporters
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沈阳化工大学材料科学与工程学院沈阳 110142