Citation: Hu Wu, Ge Cao, Mingyang Liu, Hainan Xu, Meng Li, Hanwei Huang, Yujie Liu, Xu Zhao, Xifeng Qin, Onder Ergonul, Füsun Can, Funan Liu, Zhiqing Pang, Jiaming Zhu. Tumor cell membrane biomimetic liposomes-coated oncolytic viruses to target the homotypic tumor and augment the antitumor efficacy[J]. Chinese Chemical Letters, ;2025, 36(7): 110493. doi: 10.1016/j.cclet.2024.110493 shu

Tumor cell membrane biomimetic liposomes-coated oncolytic viruses to target the homotypic tumor and augment the antitumor efficacy

Hu Wu ^{a, b, c, 1} ,
Ge Cao ^{a, c, 1} ,
Mingyang Liu ^{a, b, c, 1} ,
Hainan Xu ^{d, 1} ,
Meng Li ^{e, 1} ,
Hanwei Huang ^{a, b, c} ,
Yujie Liu ^{a, c} ,
Xu Zhao ^{a, b, c} ,
Xifeng Qin ^b ,
Onder Ergonul ^f ,
Füsun Can ^f ,
Funan Liu ^{a, c, g, *,} ,
Zhiqing Pang ^{b, *,} ,
Jiaming Zhu ^{a, c, *,}

a.
Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang 110001, China
b.
Department of Pharmaceutics, School of Pharmacy, Fudan University and Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China
c.
Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang 110001, China
d.
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, China
e.
Department of Gynecology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110031, China
f.
Koç University Iş Bank Center for Infectious Diseases (KUISCID), Koç University School of Medicine and American Hospital, Istanbul 34450, Turkey
g.
Phase I Clinical Trials Center, The First Hospital, China Medical University, Shenyang 110102, China

fnliu@cmu.edu.cn

zqpang@fudan.edu.cn

zhujiaming75@sina.com

Received Date: 20 June 2024
Revised Date: 19 September 2024
Accepted Date: 23 September 2024
Available Online: 24 September 2024

Figures(5)

Though oncolytic viruses (OVs) hold significant potential for comprehensive treatment of malignant tumors, their systemic administration faces substantial challenges such as insufficient circulation time, inadequate tumor targeting, and spontaneous antiviral immune response of the body, which seriously limits the clinical application of OVs. Herein, we proposed a tumor targeting strategy of tumor cell membrane biomimetic liposomes to encapsulate OVs for intravenous delivery, which enables OVs to target the homotypic tumor lesions and exert their oncolytic effect. On the one hand, this cell membrane biomimetic carrier enhanced the encapsulation of OVs by the hybrid lipid membranes, concealed the viral capsid proteins, and diminished the neutralization and clearance of the virions from the bloodstream. On the other hand, enhanced tumor targeted delivery can be achieved through the utilization of homologous adhesion molecules on the surface of tumor cell membrane. In addition, this strategy also promoted the tumor infiltration of CD4⁺, CD8⁺ T cells mediated by the oncolytic effect of OVs and increased the levels of inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the tumor, thereby effectively enhancing the anti-tumor effect of intravenous administration of OVs. The findings of our study demonstrate that T-L@Ad11 offers a handy and efficient approach for targeting tumors, thereby enhancing the antitumor efficacy of intravenous administration of OVs.
- Oncolytic virus,
- Tumor cell membrane,
- Hybrid nanovesicle,
- Homologous targeting,
- Systemic administration
1. [1]
  H.L. Kaufman, F.J. Kohlhapp, A. Zloza, Nat. Rev. Drug Discov. 15 (2016) 660. doi: 10.1038/nrd.2016.178
2. [2]
  T. Todo, H. Ito, Y. Ino, et al., Nat. Med. 28 (2022) 1630–1639. doi: 10.1038/s41591-022-01897-x
3. [3]
  A. Melcher, K. Harrington, R. Vile, Science 374 (2021) 1325–1326. doi: 10.1126/science.abk3436
4. [4]
  S. Gujar, J. Bell, J.S. Diallo, Cell 176 (2019) 1240-1240. e1241.
5. [5]
  T. Guo, X.L. Liu, Z.K. Zhang, et al., Chin. Chem. Lett. 32 (2021) 3962–3966.
6. [6]
  H. Fukuhara, Y. Ino, T. Todo, Cancer Sci. 107 (2016) 1373–1379. doi: 10.1111/cas.13027
7. [7]
  L.Q. Fu, X.B. Ma, Y.T. Liu, Z.G. Xu, Z.J. Sun, Chin. Chem. Lett. 33 (2022) 1718–1728.
8. [8]
  Y. Tian, D. Xie, L. Yang, Signal Transduct. Target. Ther. 7 (2022) 117.
9. [9]
  M. Zheng, J. Huang, A. Tong, H. Yang, Mol. Ther. Oncolyt. 15 (2019) 234–247.
10. [10]
  K. Twumasi-Boateng, J.L. Pettigrew, Y.Y.E. Kwok, J.C. Bell, B.H. Nelson, Nat. Rev. Cancer 18 (2018) 526. doi: 10.1038/s41568-018-0019-2
11. [11]
  W. Ban, J. Guan, H. Huang, et al., Nano Res. 15 (2022) 4137–4153. doi: 10.1007/s12274-021-4031-6
12. [12]
  R.A. Adair, V. Roulstone, K.J. Scott, et al., Sci. Transl. Med. 4 (2012) 138ra177.
13. [13]
  S. Atasheva, C.C. Emerson, J. Yao, et al., Sci. Transl. Med. 12 (2020) eabc6659.
14. [14]
  J.Y. Tan, J.Y. Zhang, C. Hu, et al., Acta Pharm. Sin. B 14 (2024) 2554–2566.
15. [15]
  K. Harrington, D.J. Freeman, B. Kelly, J. Harper, J. -C. Soria, Nat. Rev. Drug Discov. 18 (2019) 689–706. doi: 10.1038/s41573-019-0029-0
16. [16]
  Y. Wang, Z. Yang, S. Liu, et al., Br. J. Cancer 92 (2005) 1414–1420. doi: 10.1038/sj.bjc.6602494
17. [17]
  T.Y. Na, L. Schecterson, A.M. Mendonsa, B.M. Gumbiner, Proc. Natl. Acad. Sci. U.S.A. 117 (2020) 5931–5937. doi: 10.1073/pnas.1918167117
18. [18]
  C. Chen, S. Zhao, A. Karnad, J.W. Freeman, J. Hematol. Oncol. 11 (2018) 64. doi: 10.1145/3210284.3210287
19. [19]
  L.L. Huang, W. Wang, Z. Wang, et al., Adv. Funct. Mater. 33 (2023) 2209056.
20. [20]
  T. Peng, J. Yao, J. Zhejiang Univ. Sci. B 23 (2022) 770–777. doi: 10.1631/jzus.b2200156
21. [21]
  Y.L. He, S.Q. Zhang, Y.G. She, et al., Exploration 4 (2024), 20230164. doi: 10.1002/EXP.20230164
22. [22]
  H.H. Wong, G. Jiang, R. Gangeswaran, et al., Mol. Ther. 20 (2012) 306–316. doi: 10.1038/mt.2011.242
23. [23]
  H.W. Huang, M.C. Sun, M.Y. Liu, et al., Nano Today 47 (2022) 101671.
24. [24]
  N. Patsoukis, Q. Wang, L. Strauss, V.A. Boussiotis, Sci. Adv. 6 (2020) eabd2712.
25. [25]
  X.Y. Wang, C.C. Ma, R. Rodríguez Labrada, et al., Sci. China Life Sci. 64 (2021) 1842–1857. doi: 10.1007/s11427-021-1952-5
26. [26]
  C. Xu, K.M. Cheng, X.W. Wang, et al., Nano Today 51 (2023) 101922.
27. [27]
  K. Laky, A.M. Kruisbeek, Curr. Protoc. Immunol. 113 (2016) 4.1.1-4.1.9.
28. [28]
  T. Hu, Y. Huang, J. Liu, et al., Pharmaceutics 15 (2023) 1821. doi: 10.3390/pharmaceutics15071821
29. [29]
  Q. Xia, Y. Zhang, Z. Li, X. Hou, N. Feng, Acta Pharm. Sin. B 9 (2019) 675–689.
30. [30]
  H. Tian, Z. Luo, L. Liu, et al., Adv. Funct. Mater. 27 (2017) 1703197.
31. [31]
  R.H. Fang, C.M.J. Hu, B.T. Luk, et al., Nano Lett. 14 (2014) 2181–2188. doi: 10.1021/nl500618u
32. [32]
  T.T. Hu, C. Shen, X.Y. Wang, F.B. Wu, Z.Y. He, Chin. Chem. Lett. 35 (2024) 109562.
33. [33]
  Y.Y. Xu, J.Y. Xiong, X.Y. Sun, H.L. Gao, Acta Pharm. Sin. B 12 (2022) 4327–4347.
34. [34]
  R. Liu, C. Luo, Z.Q. Pang, et al., Chin. Chem. Lett. 34 (2023) 107518.
35. [35]
  H. Liu, Z.H. Miao, Z.B. Zha, Chin. Chem. Lett. 33 (2022) 1673–1680.
36. [36]
  Y.Z. Ren, H.Q. Jing, Y. Zhou, et al., Chin. Chem. Lett. 34 (2023) 108161.
37. [37]
  J. Xiong, M. Wu, J. Chen, et al., ACS Nano 15 (2021) 19756–19770. doi: 10.1021/acsnano.1c07180
38. [38]
  J. Hong, M. Jung, C. Kim, et al., Exp. Mol. Med. 55 (2023) 541–554. doi: 10.1038/s12276-023-00951-z
39. [39]
  Y. Jiang, N. Krishnan, J. Zhou, et al., Adv. Mater. 32 (2020) e2001808.
40. [40]
  M.E. Aikins, C. Xu, J.J. Moon, Acc. Chem. Res. 53 (2020) 2094–2105. doi: 10.1021/acs.accounts.0c00456
41. [41]
  X. Wang, N. Wang, Y. Yang, et al., Biomater. Sci. 7 (2019) 3062–3075. doi: 10.1039/c9bm00010k
42. [42]
  F.Y. Huang, S.Z. Dai, J.Y. Wang, et al., Biomaterials 278 (2021) 121141.
43. [43]
  K.L. Oxley, B.M. Hanson, A.N. Zani, G.A. Bishop, Cancer Immunol. Immunother. 70 (2021) 3093–3103. doi: 10.1007/s00262-021-02914-7
44. [44]
  H. Ogino, J.W. Taylor, T. Nejo, et al., J. Clin. Invest. 132 (2022) e151239.
45. [45]
  A. Harari, M. Graciotti, M. Bassani-Sternberg, L.E. Kandalaft, Nat. Rev. Drug Discov. 19 (2020) 635–652. doi: 10.1038/s41573-020-0074-8
46. [46]
  C.C. Feng, P. Tan, G.J. Nie, M.T. Zhu, Exploration 3 (2023) 20210263.
1. [1]
  Xiaoyu Hou , Mingyang Liu , Hu Wu , Nan Wang , Xu Zhao , Xifeng Qin , Xiaomin Su , Hanwei Huang , Zihan Ma , Jiahao Liu , Onder Ergonul , Füsun Can , Wei Liu , Zhiqing Pang , Funan Liu . Differential releasing hydrogel loaded with oncolytic viruses and anti-CAFs drug to enhance oncology therapeutic efficacy. Chinese Chemical Letters, 2025, 36(5): 110106-. doi: 10.1016/j.cclet.2024.110106
2. [2]
  Yanfei Liu , Yaqin Hu , Yifu Tan , Qiwen Chen , Zhenbao Liu . Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition. Chinese Chemical Letters, 2025, 36(1): 110289-. doi: 10.1016/j.cclet.2024.110289
3. [3]
  Ying Gao , Rong Zhou , Qiwen Wang , Shaolong Qi , Yuanyuan Lv , Shuang Liu , Jie Shen , Guocan Yu . Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy. Chinese Chemical Letters, 2024, 35(10): 109521-. doi: 10.1016/j.cclet.2024.109521
4. [4]
  Yuanzheng Wang , Chen Zhang , Shuyan Han , Xiaoli Kong , Changyun Quan , Jun Wu , Wei Zhang . Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition. Chinese Chemical Letters, 2024, 35(11): 109578-. doi: 10.1016/j.cclet.2024.109578
5. [5]
  Cheng-Zhe Gao , Hao-Ran Jia , Tian-Yu Wang , Xiao-Yu Zhu , Xiaofeng Han , Fu-Gen Wu . A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy. Chinese Chemical Letters, 2025, 36(1): 109840-. doi: 10.1016/j.cclet.2024.109840
6. [6]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
7. [7]
  Ji Liu , Dongsheng He , Tianjiao Hao , Yumin Hu , Yan Zhao , Zhen Li , Chang Liu , Daquan Chen , Qiyue Wang , Xiaofei Xin , Yan Shen . Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy. Chinese Chemical Letters, 2024, 35(9): 109296-. doi: 10.1016/j.cclet.2023.109296
8. [8]
  Jisheng Liu , Junli Chen , Xifeng Zhang , Yin Wu , Xin Qi , Jie Wang , Xiang Gao . Red blood cell membrane-coated FLT3 inhibitor nanoparticles to enhance FLT3-ITD acute myeloid leukemia treatment. Chinese Chemical Letters, 2024, 35(9): 109779-. doi: 10.1016/j.cclet.2024.109779
9. [9]
  Bairui Zeng , Zhixiang Mu , Tianxi Shen , Xiaoliang Qi , Yuanqi Chen , Kezheng Lei , Chen Huang , Yi Wang , Rongdang Hu , Xiaojun Cai , Jianliang Shen , Hui Deng . A self-propelled nanovesicle with robust antibacterial and regeneration-promoting capabilities for treating biofilm-induced periodontitis. Chinese Chemical Letters, 2025, 36(6): 110350-. doi: 10.1016/j.cclet.2024.110350
10. [10]
  Cheng Wang , Ji Wang , Dong Liu , Zhi-Ling Zhang . Advances in virus-host interaction research based on microfluidic platforms. Chinese Chemical Letters, 2024, 35(12): 110302-. doi: 10.1016/j.cclet.2024.110302
11. [11]
  Yu Yan , Jiawei Song , Dongdong Liu , Zihan Liu , Jialing Cheng , Zhiyang Chen , Yanfang Yang , Weizhe Jiang , Hongliang Wang , Jun Ye , Yuling Liu . Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis. Chinese Chemical Letters, 2024, 35(6): 109736-. doi: 10.1016/j.cclet.2024.109736
12. [12]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
13. [13]
  Yuxin Tian , Mengjun Li , Yang Yang , Chunhui Li , Yun Peng , Haiyin Yang , Mengyuan Zhao , Pengfei Wu , Shaobo Ruan , Yuanyu Huang , Chenguang Shen , Minghui Yang . An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus. Chinese Chemical Letters, 2024, 35(8): 109270-. doi: 10.1016/j.cclet.2023.109270
14. [14]
  Jia-Li Xie , Tian-Jin Xie , Yu-Jie Luo , Kai Mao , Cheng-Zhi Huang , Yuan-Fang Li , Shu-Jun Zhen . Octopus-like DNA nanostructure coupled with graphene oxide enhanced fluorescence anisotropy for hepatitis B virus DNA detection. Chinese Chemical Letters, 2024, 35(6): 109137-. doi: 10.1016/j.cclet.2023.109137
15. [15]
  Ji Zhang , Tong Zhang , Qiao An , Peng Zhang , Cai-Yan Tian , Chun-Mao Yuan , Ping Yi , Zhan-Xing Hu , Xiao-Jiang Hao . Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora. Chinese Chemical Letters, 2024, 35(6): 108927-. doi: 10.1016/j.cclet.2023.108927
16. [16]
  Chao Chen , Wenwen Yu , Guangen Huang , Xuelian Ren , Xiangli Chen , Yixin Li , Shenggui Liang , Mengmeng Xu , Mingyue Zheng , Yaxi Yang , He Huang , Wei Tang , Bing Zhou . Asymmetric macrocyclization enabled by Rh(Ⅲ)-catalyzed CH activation: Enantioenriched macrocyclic inhibitor of Zika virus infection. Chinese Chemical Letters, 2024, 35(11): 109574-. doi: 10.1016/j.cclet.2024.109574
17. [17]
  Shaoqing Du , Xinyong Liu , Xueping Hu , Peng Zhan . Targeting novel sites represents an effective strategy for combating drug resistance. Chinese Chemical Letters, 2025, 36(1): 110378-. doi: 10.1016/j.cclet.2024.110378
18. [18]
  Lu-Lu He , Lan-Tu Xiong , Xin Wang , Yu-Zhen Li , Jia-Bao Li , Yu Shi , Xin Deng , Zi-Ning Cui . Application of inhibitors targeting the type III secretion system in phytopathogenic bacteria. Chinese Chemical Letters, 2025, 36(4): 110044-. doi: 10.1016/j.cclet.2024.110044
19. [19]
  Haiyang Gu , Xiang Xu . Multicolor hybrid metal halides and anti-counterfeiting. Chinese Journal of Structural Chemistry, 2024, 43(9): 100352-100352. doi: 10.1016/j.cjsc.2024.100352
20. [20]
  Wenjing Dai , Lan Luo , Zhen Yin . Interface reconstruction of hybrid oxide electrocatalysts for seawater oxidation. Chinese Journal of Structural Chemistry, 2025, 44(3): 100442-100442. doi: 10.1016/j.cjsc.2024.100442

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(4)
HTML views(1)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142