Citation: Qijie Gong, Jian Song, Yihui Song, Kai Tang, Panpan Yang, Xiao Wang, Min Zhao, Liang Ouyang, Li Rao, Bin Yu, Peng Zhan, Saiyang Zhang, Xiaojin Zhang. New techniques and strategies in drug discovery (2020–2024 update)[J]. Chinese Chemical Letters, ;2025, 36(3): 110456. doi: 10.1016/j.cclet.2024.110456 shu

New techniques and strategies in drug discovery (2020–2024 update)

Qijie Gong ^{a, 1} ,
Jian Song ^{b, 1} ,
Yihui Song ^{c, 1} ,
Kai Tang ^{d, 1} ,
Panpan Yang ^{e, 1} ,
Xiao Wang ^b ,
Min Zhao ^e ,
Liang Ouyang ^{e, *,} ,
Li Rao ^{f, *,} ,
Bin Yu ^{g, *,} ,
Peng Zhan ^{d, *,} ,
Saiyang Zhang ^{b, *,} ,
Xiaojin Zhang ^{a, *,}

a.
Jiangsu Key Laboratory of Drug Design and Optimization, and Department of Chemistry, China Pharmaceutical University, Nanjing 211198, China
b.
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China
c.
School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou 450001, China
d.
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji’nan 250012, China
e.
State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China
f.
National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan 430079, China
g.
College of Chemistry, Pingyuan Laboratory, Zhengzhou University, Zhengzhou 450001, China

ouyangliang@scu.edu.cn

raoli@ccnu.edu.cn

yubin@zzu.edu.cn

zhanpeng1982@sdu.edu.cn

saiyangz@zzu.edu.cn

zxj@cpu.edu.cn

Received Date: 12 July 2024
Revised Date: 11 September 2024
Accepted Date: 12 September 2024
Available Online: 13 September 2024

Figures(6)

In the realm of drug discovery, recent advancements have paved the way for innovative approaches and methodologies. This comprehensive review encapsulates six distinct yet interrelated mini-reviews, each shedding light on novel strategies in drug development. (a) The resurgence of covalent drugs is highlighted, focusing on the targeted covalent inhibitors (TCIs) and their role in enhancing selectivity and affinity. (b) The potential of the quantum mechanics-based computational aid drug design (CADD) tool, Cov_DOX, is introduced for predicting protein-covalent ligand binding structures and affinities. (c) The scaffolding function of proteins is proposed as a new avenue for drug design, with a focus on modulating protein-protein interactions through small molecules and proteolysis targeting chimeras (PROTACs). (d) The concept of pro-PROTACs is explored as a promising strategy for cancer therapy, combining the principles of prodrugs and PROTACs to enhance specificity and reduce toxicity. (e) The design of prodrugs through carbon-carbon bond cleavage is discussed, offering a new perspective for the activation of drugs with limited modifiable functional groups. (f) The targeting of programmed cell death pathways in cancer therapies with small molecules is reviewed, emphasizing the induction of autophagy-dependent cell death, ferroptosis, and cuproptosis. These insights collectively contribute to a deeper understanding of the dynamic landscape of drug discovery.
- Drug discovery,
- Covalent inhibitors,
- Computational drug design,
- Protein scaffolding,
- Pro-PROTACs,
- Programmed cell death,
- C-C cleavage
1. [1]
  J. Du, J. Guo, D. Kang, et al., Chin. Chem. Lett. 31 (2020) 1695–1708. doi: 10.1016/j.cclet.2020.03.028
2. [2]
  J. Singh, R.C. Petter, T.A. Baillie, A. Whitty, Nat. Rev. Drug Disc. 10 (2011) 1474–1784. doi: 10.1038/nrd3410
3. [3]
  J. Uetrecht, Annu. Rev. Pharmacol. Toxicol. 47 (2007) 513–539. doi: 10.1146/annurev.pharmtox.47.120505.105150
4. [4]
  L. Boike, N.L. Henning, D.K. Nomura, Nat. Rev. Drug Disc. 21 (2022) 881–898. doi: 10.1038/s41573-022-00542-z
5. [5]
  H. Kim, Y.S. Hwang, M. Kim, S.B. Park, RSC Med. Chem. 12 (2021) 1037–1045. doi: 10.1039/d1md00068c
6. [6]
  X. Shao, S. Xu, X. Wan, et al., Chin. Chem. Lett. 34 (2023) 108349. doi: 10.1016/j.cclet.2023.108349
7. [7]
  S. Gao, T. Huang, L. Song, et al., Acta Pharm. Sin. B 12 (2022) 581–599. doi: 10.1016/j.apsb.2021.08.027
8. [8]
  T.A. Baillie, Angew. Chem. Int. Ed. 55 (2016) 13408–13421. doi: 10.1002/anie.201601091
9. [9]
  E. Mons, S. Roet, R.Q. Kim, M.P.C. Mulder, Curr. Protoc. 2 (2022) e419. doi: 10.1002/cpz1.419
10. [10]
  J.M. Strelow, SLAS Discov. 22 (2017) 3–20. doi: 10.1177/1087057116671509
11. [11]
  M.E. Flanagan, J.A. Abramite, D.P. Anderson, et al., J. Med. Chem. 57 (2014) 10072–10079. doi: 10.1021/jm501412a
12. [12]
  M. Gehringer, S.A. Laufer, J. Med. Chem. 62 (2019) 5673–5724. doi: 10.1021/acs.jmedchem.8b01153
13. [13]
  X. Pang, W. Xu, Y. Liu, H. Li, L. Chen, Eur. J. Med. Chem. 257 (2023) 115491. doi: 10.1016/j.ejmech.2023.115491
14. [14]
  M. Berry, B.C. Fielding, J. Gamieldien, Viruses 7 (2015) 6642–6660. doi: 10.3390/v7122963
15. [15]
  D.W. Kneller, G. Phillips, H.M. O'Neill, et al., Nat. Commun. 11 (2020) 3202. doi: 10.1038/s41467-020-16954-7
16. [16]
  A. Citarella, A. Dimasi, D. Moi, et al., Biomolecules 13 (2023) 1339. doi: 10.3390/biom13091339
17. [17]
  S. Iketani, F. Forouhar, H. Liu, et al., Nat. Commun. 12 (2021) 2708. doi: 10.1038/s41467-021-23082-3
18. [18]
  D.R. Owen, C.M.N. Allerton, A.S. Anderson, et al., Science 374 (2021) 1586–1593. doi: 10.1126/science.abl4784
19. [19]
  Z. Jin, X. Du, Y. Xu, et al. Nature 582 (2020) 289–293. doi: 10.1038/s41586-020-2223-y
20. [20]
  C. Ma, M.D. Sacco, B. Hurst, et al. Cell Res. 30 (2020) 678–692. doi: 10.1038/s41422-020-0356-z
21. [21]
  X. Ye, P. Zhang, J. Tao, et al., Pentelute, Chem. Sci. 14 (2023) 12484–12497. doi: 10.1039/d3sc02782a
22. [22]
  S. Gao, L. Song, T. Claff, et al., J. Med. Chem. 65 (2022) 16902–16917. doi: 10.1021/acs.jmedchem.2c01716
23. [23]
  K. Amporndanai, X. Meng, W. Shang, et al., Nat. Commun. 12 (2021) 3061. doi: 10.1038/s41467-021-23313-7
24. [24]
  J. Karges, M. Kalaj, M. Gembicky, S.M. Cohen, Angew. Chem. Int. Ed. 60 (2021) 10716–10723. doi: 10.1002/anie.202016768
25. [25]
  W.M. McFadden, M.C. Casey-Moore, G.A.L. Bare, et al. Cell Chem. Biol. 31 (2024) 477–486. doi: 10.1016/j.chembiol.2024.02.012
26. [26]
  S. Thenin-Houssier, I.M. de Vera, L. Pedro-Rosa, et al., Antimicrob. Agents Chemother. 60 (2016) 2195–2208. doi: 10.1128/AAC.02574-15
27. [27]
  D.A. Nyenhuis, R. Rajasekaran, S. Watanabe, et al., J. Biol. Chem. 299 (2023) 102901. doi: 10.1016/j.jbc.2023.102901
28. [28]
  D.A. Nyenhuis, S. Watanabe, R. Bernstein, et al. Adv. Sci. 11 (2024) e2308312. doi: 10.1002/advs.202308312
29. [29]
  A. Scarpino, G.G. Ferenczy, G.M. Keseru, J. Chem. Inf. Model. 58 (2018) 1441–1458. doi: 10.1021/acs.jcim.8b00228
30. [30]
  C. Wen, X. Yan, Q. Gu, et al. Molecules, 24 (2019) 2183. doi: 10.3390/molecules24112183
31. [31]
  L. Wei, Y. Chen, J. Liu, et al., J. Med. Chem. 65 (2022) 5528–5538. doi: 10.1021/acs.jmedchem.1c02007
32. [32]
  L. Wei, B. Chi, Y. Ren, et al., J. Chem. Theory Comput. 7 (2019) 4264–4279. doi: 10.1021/acs.jctc.8b01150
33. [33]
  J. Chai, M. Head-Gordon, Phy. Chem. Chem. Phy. 10 (2008) 6615. doi: 10.1039/b810189b
34. [34]
  W. Guo, A. Wu, I.Y. Zhang, X. Xu, J. Comput. Chem. 33 (2012) 2142–2160. doi: 10.1002/jcc.23051
35. [35]
  J. Liu, J. Wan, Y. Ren, et al., J. Chem. Inf. Model. 63 (2023) 4850–4863. doi: 10.1021/acs.jcim.3c00776
36. [36]
  P.D. Mace, J.M. Murphy, J. Biol. Chem. (2021) 100705. doi: 10.1016/j.jbc.2021.100705
37. [37]
  Z. Wang, W. Huang, K. Zhou, X. Ren, K. Ding, J. Med. Chem. 65 (2022) 1735–1748. doi: 10.1021/acs.jmedchem.1c01978
38. [38]
  C. Kim, X.D. Wang, Z. Liu, S. Zha, Y. Yu, Biochemistry 62 (2023) 561–563. doi: 10.1021/acs.biochem.2c00366
39. [39]
  E. Shanthi, M.H. Krishna, G.M. Arunesh, et al., Expert Opin. Ther. Pat. 24 (2014) 1077–1100. doi: 10.1517/13543776.2014.948845
40. [40]
  E.V. Kurenova, D.L. Hunt, D. He, et al. J. Med. Chem. 52 (2009) 4716–4724. doi: 10.1021/jm900159g
41. [41]
  E. Kurenova, J. Liao, D.H. He, et al., Oncotarget 4 (2013) 1632–1646. doi: 10.18632/oncotarget.1365
42. [42]
  Y. Sun, R. Wang, Y. Sun, et al., Eur. J. Med. Chem. 237 (2022) 114373. doi: 10.1016/j.ejmech.2022.114373
43. [43]
  Q. Qin, R. Wang, Q. Fu, et al., J. Enzyme Inh. Med. Chem. 37 (2022) 2241–2255. doi: 10.1080/14756366.2022.2100886
44. [44]
  P.M. Cromm, K.T.G. Samarasinghe, J. Hines, C.M. Crews, J. Am. Chem. Soc. 140 (2018) 17019–17026. doi: 10.1021/jacs.8b08008
45. [45]
  G. Yang, C. Li, F. Tao, et al., Genes Dis. 11 (2024) 645–663. doi: 10.1016/j.gendis.2022.12.020
46. [46]
  R.M. Labbé, A. Holowatyj, Z.Q. Yang, Am. J. Transl. Res. 6 (2014) 1–15.
47. [47]
  Q. Wu, B. Young, Y. Wang, et al. J. Med. Chem. 65 (2022) 9564–9579. doi: 10.1021/acs.jmedchem.2c00680
48. [48]
  A.K. Upadhyay, R.A. Judge, L. Li, et al., Bioorg. Med. Chem. Lett. 28 (2018) 1708–1713. doi: 10.1016/j.bmcl.2018.04.050
49. [49]
  L.E. Powell, P.A. Foster, Cancer Med. 10 (2021) 2812–2825. doi: 10.1002/cam4.3836
50. [50]
  S. Xu, Y. Liu, K. Yang, et al., Theranostics 9 (2019) 2282–2298. doi: 10.7150/thno.30621
51. [51]
  K. Li, C.M. Crews, Chem. Soc. Rev. 51 (2022) 5214–5236. doi: 10.1039/d2cs00193d
52. [52]
  M. Békés, D.R. Langley, C.M. Crews, Nat. Rev. Drug Disc. 21 (2022) 181–200. doi: 10.1038/s41573-021-00371-6
53. [53]
  C. Chen, Y. Yang, Z. Wang, et al. J. Med. Chem. 66 (2023) 8428–8440. doi: 10.1021/acs.jmedchem.3c00302
54. [54]
  C. Pu, S. Wang, L. Liu, et al., Chin. Chem. Lett. 34 (2023) 107927. doi: 10.1016/j.cclet.2022.107927
55. [55]
  G. Xue, K. Wang, D. Zhou, H. Zhong, Z. Pan, J. Am. Chem. Soc. 141 (2019) 18370–18374. doi: 10.1021/jacs.9b06422
56. [56]
  H. Xu, N. Ohoka, T. Inoue, H. Yokoo, Y. Demizu, Bioorg. Med. Chem. Lett. 107 (2024) 129778. doi: 10.1016/j.bmcl.2024.129778
57. [57]
  P.S. Dragovich, Chem. Soc. Rev. 51 (2022) 3886–3897. doi: 10.1039/d2cs00141a
58. [58]
  K.B. Hong, H. An, J. Med. Chem. 66 (2023) 140–148. doi: 10.1021/acs.jmedchem.2c01791
59. [59]
  J. Liu, H. Chen, Y. Liu, et al. J. Am. Chem. Soc. 143 (2021) 7380–7387. doi: 10.1021/jacs.1c00451
60. [60]
  H. Chen, J. Liu, H. Kaniskan, W. Wei, J. Jin, J. Med. Chem. 64 (2021) 12273–12285. doi: 10.1021/acs.jmedchem.1c00901
61. [61]
  S. He, F. Gao, J. Ma, et al., Angew. Chem. Int. Ed. 60 (2021) 23299–23305. doi: 10.1002/anie.202107347
62. [62]
  S. He, Y. Fang, Y. Zhu, et al., Adv. Sci. 11 (2024) e2401623. doi: 10.1002/advs.202401623
63. [63]
  W. Cheng, S. Li, X. Wen, et al., Chem. Commun. 57 (2021) 12852–12855. doi: 10.1039/d1cc05715d
64. [64]
  S. Shi, Y. Du, Y. Zou, et al., J. Med. Chem. 65 (2022) 5057–5071. doi: 10.1021/acs.jmedchem.1c02221
65. [65]
  C. Yang, Y. Yang, Y. Li, et al., J. Am. Chem. Soc. 145 (2023) 385–391. doi: 10.1021/jacs.2c10177
66. [66]
  C. Liang, Q. Zheng, T. Luo, et al., CCS Chem. 4 (2022) 3809–3819. doi: 10.31635/ccschem.022.202101529
67. [67]
  H. Liu, C. Ren, R. Sun, et al., Chem. Commun. 58 (2022) 10072–10075. doi: 10.1039/d2cc03367d
68. [68]
  J. Rautio, N.A. Meanwell, L. Di, M.J. Hageman, Nat. Rev. Drug Disc. 17 (2018) 559–587. doi: 10.1038/nrd.2018.46
69. [69]
  S. Gnaim, D. Shabat, Acc. Chem. Res. 52 (2019) 2806–2817. doi: 10.1021/acs.accounts.9b00338
70. [70]
  A.G. Atanasov, S.B. Zotchev, V.M.C. Dirsch, C.T. Supuran, Nat. Rev. Drug Disc. 20 (2021) 200–216. doi: 10.1038/s41573-020-00114-z
71. [71]
  D. Dey, M.M. Hasan, P. Biswas, et al., Front. Oncol. 12 (2022) 899009. doi: 10.3389/fonc.2022.899009
72. [72]
  Q. Gong, J. Hu, P. Wang, X. Li, X. Zhang, Eur. J. Med. Chem. 210 (2020) 112962.
73. [73]
  M.A. Ansari, F.B. Khan, H.A. Safdari, et al., Pharmacol. Res. 164 (2021) 105364. doi: 10.1016/j.phrs.2020.105364
74. [74]
  X. Zhang, X. Li, Q. You, X. Zhang, Eur. J. Med. Chem. 139 (2017) 542–563. doi: 10.1016/j.ejmech.2017.08.010
75. [75]
  P. Wang, Q. Gong, J. Hu, X. Li, X. Zhang, J. Med. Chem. 64 (2021) 298–325. doi: 10.1021/acs.jmedchem.0c01704
76. [76]
  Q. Gong, X. Li, T. Li, et al., Angew. Chem. Int. Ed. 61 (2022) e202210001. doi: 10.1002/anie.202210001
77. [77]
  L. Dunsmore, C.D. Navo, J. Becher, et al., Nat. Chem. 14 (2022) 754–765. doi: 10.1038/s41557-022-00964-7
78. [78]
  J. Wang, X. Wang, X. Fan, P. Chen, ACS Cent. Sci. 7 (2021) 929–943. doi: 10.1021/acscentsci.1c00124
79. [79]
  J.T. Weiss, J.C. Dawson, K.G. Macleod, et al., Nat. Commun. 5 (2014) 3277. doi: 10.1038/ncomms4277
80. [80]
  G.M. Dal Forno, E. Latocheski, A. Beatriz Machado, et al., J. Am. Chem. Soc. 145 (2023) 10790–10799. doi: 10.1021/jacs.3c01960
81. [81]
  H.H. Han, H.M. Wang, P. Jangili, et al., Chem. Soc. Rev. 52 (2023) 879–920. doi: 10.1039/d2cs00673a
82. [82]
  E.G. Kaye, B. Mirabi, I.R. Lopez-Miranda, et al., J. Am. Chem. Soc. 145 (2023) 12518–12531. doi: 10.1021/jacs.3c00398
83. [83]
  S. Bedoui, M.J. Herold, A. Strasser, Nat. Rev. Mol. Cell Biol. 21 (2020) 678–695. doi: 10.1038/s41580-020-0270-8
84. [84]
  K. Hadian, B.R. Stockwell, Nat. Rev. Drug Disc. 22 (2023) 723–742. doi: 10.1038/s41573-023-00749-8
85. [85]
  L. Galluzzi, I. Vitale, S.A. Aaronson, et al. Cell Death Diff. 25 (2018) 486–541. doi: 10.1038/s41418-017-0012-4
86. [86]
  D. Tang, R. Kang, T. Berghe, P. Vandenabeele, G. Kroemer, Cell Res. 29 (2019) 347–364. doi: 10.1038/s41422-019-0164-5
87. [87]
  S.W. Leong, J. Wang, K.S. Okuda, et al. Eur. J. Med. Chem. 254 (2023) 115335. doi: 10.1016/j.ejmech.2023.115335
88. [88]
  J. Kim, A. Park, J. Hwang, et al., Cell Rep. 40 (2022) 111077. doi: 10.1016/j.celrep.2022.111077
89. [89]
  L. Cai, Z.R. Wu, L. Cao, et al., Acta Pharmacol. Sin. 43 (2022) 2386–2396. doi: 10.1038/s41401-021-00856-5
90. [90]
  X. Tong, R. Tang, M. Xiao, et al., J. Hematol. Oncol. 15 (2022) 174. doi: 10.1186/s13045-022-01392-3
91. [91]
  S. Liu, H.L. Zhang, J. Li, et al., Redox Biol. 62 (2023) 102677. doi: 10.1016/j.redox.2023.102677
92. [92]
  H. Zhao, M. Zhang, J. Zhang, et al., Cell Biosci. 13 (2023) 87. doi: 10.3390/fermentation9020087
93. [93]
  L. Zhang, W. Liu, F. Liu, et al., Oxid. Med. Cell. Longev. 2020 (2020) 1675613.
94. [94]
  P. Tsvetkov, S. Coy, B. Petrova, et al., Science 375 (2022) 1254–1261. doi: 10.1126/science.abf0529
95. [95]
  Y. Wang, L. Zhang, F. Zhou, Cell. Mol. Immunol. 19 (2022) 867–868. doi: 10.1038/s41423-022-00866-1
96. [96]
  W. Yang, Y. Wang, Y. Huang, et al., Biomed. Pharmacother. 159 (2023) 114301. doi: 10.1016/j.biopha.2023.114301
97. [97]
  Y. Wang, Y. Chen, J. Zhang, et al., Drug Resist. Updat. 72 (2024) 101018. doi: 10.1016/j.drup.2023.101018
1. [1]
  Yang Feng , Yang-Qing Tian , Yong-Qiang Zhao , Sheng-Jun Chen , Bi-Feng Yuan . Dynamic deformylation of 5-formylcytosine and decarboxylation of 5-carboxylcytosine during differentiation of mouse embryonic stem cells into mouse neurons. Chinese Chemical Letters, 2024, 35(11): 109656-. doi: 10.1016/j.cclet.2024.109656
2. [2]
  Jiajun Wang , Guolin Yi , Shengling Guo , Jianing Wang , Shujuan Li , Ke Xu , Weiyi Wang , Shulai Lei . Computational design of bimetallic TM₂@g-C₉N₄ electrocatalysts for enhanced CO reduction toward C₂ products. Chinese Chemical Letters, 2024, 35(7): 109050-. doi: 10.1016/j.cclet.2023.109050
3. [3]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
4. [4]
  Mianling Yang , Meehyein Kim , Peng Zhan . Modular miniaturized synthesis and in situ biological evaluation facilitate rapid discovery of potent MraY inhibitors as antibacterial agents. Chinese Chemical Letters, 2025, 36(2): 110455-. doi: 10.1016/j.cclet.2024.110455
5. [5]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
6. [6]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
7. [7]
  Shiqi Xu , Zi Ye , Shuang Shang , Fengge Wang , Huan Zhang , Lianguo Chen , Hao Lin , Chen Chen , Fang Hua , Chong-Jing Zhang . Pairs of thiol-substituted 1,2,4-triazole-based isomeric covalent inhibitors with tunable reactivity and selectivity. Chinese Chemical Letters, 2024, 35(7): 109034-. doi: 10.1016/j.cclet.2023.109034
8. [8]
  Han Yuan , Fengcai Zhang , Hongzhe Huang , Jiafei Wu , Yi Yang , Wanyi Huang , Dongjing Yang , Zhuoming Li , Zhe Li , Ling Huang , Yi-You Huang , Hai-Bin Luo , Lei Guo . Discovery of 3-trifluoromethyl-substituted pyrazoles as selective phosphodiesterase 10A inhibitors for orally attenuating isoprenaline-induced cardiac hypertrophy. Chinese Chemical Letters, 2025, 36(4): 109965-. doi: 10.1016/j.cclet.2024.109965
9. [9]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
10. [10]
  Shaoqing Du , Xinyong Liu , Xueping Hu , Peng Zhan . Targeting novel sites represents an effective strategy for combating drug resistance. Chinese Chemical Letters, 2025, 36(1): 110378-. doi: 10.1016/j.cclet.2024.110378
11. [11]
  Qinghong Zhang , Qiao Zhao , Xiaodi Wu , Li Wang , Kairui Shen , Yuchen Hua , Cheng Gao , Yu Zhang , Mei Peng , Kai Zhao . Visible-light-induced ring-opening cross-coupling of cycloalcohols with vinylazaarenes and enones via β-C-C scission enabled by proton-coupled electron transfer. Chinese Chemical Letters, 2025, 36(2): 110167-. doi: 10.1016/j.cclet.2024.110167
12. [12]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
13. [13]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
14. [14]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967
15. [15]
  Xin Zhang , Junyu Chen , Xiang Pei , Linxin Yang , Liang Wang , Luona Chen , Guangmei Yang , Xibo Pei , Qianbing Wan , Jian Wang . Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration. Chinese Chemical Letters, 2024, 35(6): 108889-. doi: 10.1016/j.cclet.2023.108889
16. [16]
  Liping Zhao , Xixi Guo , Zhimeng Zhang , Xi Lu , Qingxuan Zeng , Tianyun Fan , Xintong Zhang , Fenbei Chen , Mengyi Xu , Min Yuan , Zhenjun Li , Jiandong Jiang , Jing Pang , Xuefu You , Yanxiang Wang , Danqing Song . Novel berberine derivatives as adjuvants in the battle against Acinetobacter baumannii: A promising strategy for combating multi-drug resistance. Chinese Chemical Letters, 2024, 35(10): 109506-. doi: 10.1016/j.cclet.2024.109506
17. [17]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
18. [18]
  Fukui Shen , Yuqing Zhang , Guoqing Luan , Kaixue Zhang , Zhenzhen Wang , Yunhao Luo , Yuanyuan Hou , Gang Bai . Revealing drug targets with multimodal bioorthogonal AMPD probes through visual metabolic labeling. Chinese Chemical Letters, 2024, 35(12): 109646-. doi: 10.1016/j.cclet.2024.109646
19. [19]
  Cheng-Zhe Gao , Hao-Ran Jia , Tian-Yu Wang , Xiao-Yu Zhu , Xiaofeng Han , Fu-Gen Wu . A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy. Chinese Chemical Letters, 2025, 36(1): 109840-. doi: 10.1016/j.cclet.2024.109840
20. [20]
  Jiajia Wang , XinXin Ge , Yajing Xiang , Xiaoliang Qi , Ying Li , Hangbin Xu , Erya Cai , Chaofan Zhang , Yulong Lan , Xiaojing Chen , Yizuo Shi , Zhangping Li , Jianliang Shen . An ionic liquid functionalized sericin hydrogel for drug-resistant bacteria-infected diabetic wound healing. Chinese Chemical Letters, 2025, 36(2): 109819-. doi: 10.1016/j.cclet.2024.109819

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(89)
HTML views(6)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142