Citation: Mengyu Chen, Qinglin Zhou, Tianyun Qin, Ningyao Sun, Yuxi Chen, Yuwei Gong, Xingyi Li, Jinsong Liu. An ionic liquid-reinforced gelatin hydrogel with strong adhesion, antibacterial and anti-inflammatory properties for treating oral ulcers[J]. Chinese Chemical Letters, ;2025, 36(7): 110441. doi: 10.1016/j.cclet.2024.110441 shu

An ionic liquid-reinforced gelatin hydrogel with strong adhesion, antibacterial and anti-inflammatory properties for treating oral ulcers

Mengyu Chen ^{a, 1} ,
Qinglin Zhou ^{b, 1} ,
Tianyun Qin ^a ,
Ningyao Sun ^a ,
Yuxi Chen ^a ,
Yuwei Gong ^a ,
Xingyi Li ^{c, *,} ,
Jinsong Liu ^{a, *,}

a.
School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China
b.
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
c.
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China

lixingyi_1984@mail.eye.ac.cn

jinsong0719@wmu.edu.cn

Received Date: 5 July 2024
Revised Date: 4 September 2024
Accepted Date: 10 September 2024
Available Online: 13 September 2024

Figures(5)

Oral ulcers may greatly diminish patient life quality and potentially result in malignant transformations. Using gels or films as pseudomembrane barriers is an effective method for promoting ulcer healing. However, these pseudomembranes face challenges such as saliva flushing, dynamic changes, and the presence of abundant microorganisms in the complex oral environment. Herein, we developed an injectable, photoinduction, in situ-enhanceable oral ulcer repair hydrogel (named as GIL2) by incorporating dynamic phenylboronic acid ester bonds and imidazole ions into a methacrylated gelatin matrix. GIL2 exhibited rapid gelation (3 s), low swelling properties (1.07 g/g), robust tensile strength (56.83 kPa) and high adhesive strength (63.38 kPa), allowing it to adhere effectively to the ulcer surface. Moreover, the GIL2 demonstrated intrinsic antibacterial and antioxidant qualities. Within a diabetic rat model for oral ulcers, GIL2 effectively eased oxidative stress and decreased the inflammation present in ulcerated wounds, thereby greatly hastening the healing process of these ulcers. Together, GIL2 hydrogel demonstrates remarkable adaptability within the oral milieu, revitalizing clinical strategy advancements for treating bacterial-infected oral ulcers.
- Ionic liquids,
- Methacrylated gelatin,
- Adhesive hydrogel,
- Injectability,
- Oral ulcers
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