Citation: Guoyin Chen, Siming Xu, Zeqi Zhang, Ying Guo, Jiahao Zheng, Jialei Yang, Jie Pan, Kai Hou, Meifang Zhu. Modulus self-adaptive hydrogel optical fiber for long-term modulation of neural activity[J]. Chinese Chemical Letters, ;2025, 36(7): 110440. doi: 10.1016/j.cclet.2024.110440 shu

Modulus self-adaptive hydrogel optical fiber for long-term modulation of neural activity

Guoyin Chen ^{a, 1} ,
Siming Xu ^{b, 1} ,
Zeqi Zhang ^{a, 1} ,
Ying Guo ^a ,
Jiahao Zheng ^a ,
Jialei Yang ^a ,
Jie Pan ^{b, *,} ,
Kai Hou ^{a, *,} ,
Meifang Zhu ^{a, *,}

a.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
b.
Department of Orthodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai 200001, China

jiepan@fudan.edu.cn

houkai711@dhu.edu.cn

zhumf@dhu.edu.cn

Received Date: 4 June 2024
Revised Date: 6 September 2024
Accepted Date: 10 September 2024
Available Online: 11 September 2024

Figures(6)

Optogenetic has been widely applied in various pathogenesis investigations of neuropathic diseases since its accurate and targeted regulation of neuronal activity. However, due to the mismatch between the soft tissues and the optical waveguide, the long-term neural regulation within soft tissue (such as brain and spinal cord) by implantable optical fibers is a large challenge. Herein, we designed a modulus self-adaptive hydrogel optical fiber (MSHOF) with tunable mechanical properties (Young’ modulus was tunable in the range of 0.32–10.56 MPa) and low light attenuation (0.12–0.21 dB/cm, 472 nm laser light), which adapts to light transmission under soft tissues. These advantages of MSHOF can ensure the effectiveness of optogenetic stimulation meanwhile safeguarding the safety of the brain/materials interaction interface. In addition, this work provides more design possibilities of MSHOF for photogenetic stimuli and has significant application prospects in photomedical therapy.
- Hydrogel optical fibers,
- Optogenetics,
- Neural interfaces,
- Variable modulus,
- Biocompatibility
1. [1]
  X.Y. Liu, S.Y. Rao, W.X. Chen, et al., Nat. Methods 20 (2023) 1802–1809. doi: 10.1038/s41592-023-02020-9
2. [2]
  S. Valverde, M. Vandecasteele, C. Piette, et al., Nat. Commun. 11 (2020) 2388.
3. [3]
  S. Jiang, X. Wu, N.J. Rommelfanger, et al., Natl. Sci. Rev. 9 (2022) nwac007.
4. [4]
  G.Y. Chen, G. Wang, X.R. Tan, et al., Natl. Sci. Rev. 8 (2021) nwaa209.
5. [5]
  S. Park, H. Yuk, R.K. Zhao, et al., Nat. Commun. 12 (2021) 3435.
6. [6]
  S. Jiang, D.C. Patel, J. Kim, et al., Nat. Commun. 11 (2020) 6115.
7. [7]
  S. Shabahang, S. Kim, S.H. Yun, et al., Adv. Funct. Mater. 28 (2018) 1706635.
8. [8]
  R. Nazempour, B.Z. Zhang, Z.Y. Ye, et al., Adv. Fiber Mater. 4 (2022) 24–42. doi: 10.1007/s42765-021-00092-w
9. [9]
  X. Jin, F. Zhu, H. Mao, et al., J. Biomech. 46 (2013) 2795–2801.
10. [10]
  H. Sheng, X.M. Wang, N. Kong, et al., Extreme Mech. Lett. 30 (2019) 100510.
11. [11]
  R. Fu, W. Luo, R. Nazempour, et al., Adv. Opt. Mater. 6 (2018) 1700941.
12. [12]
  K. Hou, Y. Li, Y. Liu, et al., Polymer 123 (2017) 55–64.
13. [13]
  A.K. Yetisen, N. Jiang, A. Fallahi, et al., Adv. Mater. 29 (2017) 1606380.
14. [14]
  X. Wang, X.T. Sun, D.L. Gan, et al., Matter 5 (2022) 1204–1223.
15. [15]
  Z.K. Hu, H.J. Zhang, Z.Q. Li, et al., Chin. Chem. Lett. 35 (2024) 109527.
16. [16]
  J.Y. Sun, X.H. Zhao, W.R.K. Illeperuma, et al., Nature 489 (2012) 133–136. doi: 10.1038/nature11409
17. [17]
  Y. Sun, Y.N. Zhu, J.H. Si, et al., Chin. Chem. Lett. 36 (2025) 110012. doi: 10.1016/j.cclet.2024.110012
18. [18]
  G.Y. Chen, K. Hou, N. Yu, et al., Nat. Commun. 13 (2022) 7789.
19. [19]
  L.L. Wang, C. Zhong, D.N. Ke, et al., Adv. Opt. Mater. 6 (2018) 1800427.
20. [20]
  G.Y. Chen, S.M. Xu, Q.Q. Zhou, et al., Adv. Fiber. Mater. 5 (2023) 968–978. doi: 10.1007/s42765-023-00257-9
21. [21]
  K. Hou, H.Y. Wang, Y.Y. Lin, et al., Macromol. Rapid. Comm. 37 (2016) 1795–1801. doi: 10.1002/marc.201600430
22. [22]
  K. Hou, Z.X. Hu, I.T. Mugaanire, et al., Polymer 183 (2019) 121903.
23. [23]
  J.J. Guo, X.Y. Liu, N. Jiang, et al., Adv. Mater. 28 (2016) 10244–10249. doi: 10.1002/adma.201603160
24. [24]
  M. Choi, M. Humar, S. Kim, S.H. Yun, Adv. Mater. 27 (2015) 4081–4086. doi: 10.1002/adma.201501603
25. [25]
  T.T. Yu, J.T. Zhu, D.Y. Li, D. Zhu, iScience 24 (2021) 102178.
26. [26]
  X.Y. Wu, J.Y. Feng, J. Deng, et al., Sci. China Chem. 63 (2020) 1281–1288. doi: 10.1007/s11426-020-9779-1
27. [27]
  G.Y. Chen, T. Chen, K. Hou, et al., Carbon 127 (2018) 218–227.
28. [28]
  R. Min, X.H. Hu, L. Pereira, et al., Opt. Laser. Technol. 147 (2022) 107626.
29. [29]
  A.C. Peacock, U.J. Gibson, J. Ballato, Adv. Phys. X (2016) 114–127. doi: 10.1080/23746149.2016.1146085
30. [30]
  W.Q. Kong, C.W. Wang, C. Jia, et al., Adv. Mater. 30 (2018) e1801934.
31. [31]
  R. Rajalingham, M. Sorenson, R. Azadi, et al., Nat. Methods 18 (2021) 1112–1116. doi: 10.1038/s41592-021-01238-9
32. [32]
  A. Bansal, S. Shikha Y. Zhang, Nat. Biomed. Eng. 7 (2023) 349–369.
33. [33]
  A.V. Kravitz, B.S. Freeze, P.R.L. Parker, et al., Nature 466 (2010) 622–626. doi: 10.1038/nature09159
34. [34]
  N. Vogt, Nat. Methods 14 (2017) 763. doi: 10.1038/nmeth.4381
35. [35]
  M.A. Erickson, W.A. Banks, Pharmacol. Rev. 70 (2018) 278–314. doi: 10.1124/pr.117.014647
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