Citation: Li Li, Lin-Lin Zhang, Yansha Gao, Lu-Ying Duan, Wuying Yang, Xigen Huang, Yanping Hong, Jiaxin Hong, Lin Yuan, Limin Lu. Target self-calibration ratiometric fluorescent sensor based on facile-synthesized europium metal-organic framework for multi-color visual detection of levofloxacin[J]. Chinese Chemical Letters, ;2025, 36(7): 110436. doi: 10.1016/j.cclet.2024.110436 shu

Target self-calibration ratiometric fluorescent sensor based on facile-synthesized europium metal-organic framework for multi-color visual detection of levofloxacin

Li Li ^{a, b} ,
Lin-Lin Zhang ^a ,
Yansha Gao ^a ,
Lu-Ying Duan ^{a, *,} ,
Wuying Yang ^a ,
Xigen Huang ^a ,
Yanping Hong ^a ,
Jiaxin Hong ^a ,
Lin Yuan ^{b, *,} ,
Limin Lu ^{a, b, *,}

a.
Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Ministry of Education, Key Laboratory of Chemical Utilization of Plant Resources of Nanchang, College of Chemistry and Materials, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China
b.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

luyingduan@jxau.edu.cn

lyuan@hnu.edu.cn

lulimin816@hotmail.com

Received Date: 11 July 2024
Revised Date: 4 September 2024
Accepted Date: 9 September 2024
Available Online: 12 September 2024

Figures(5)

Developing an accurate and visual sensing strategy for trace levels of fluoroquinolone residues that pose threat to food safety and human health is highly desired but remains challenging. Herein, a target self-calibration ratiometric fluorescent sensing platform has been designed for sensitive visual detection of levofloxacin (LEV) based on fluorescent europium metal-organic framework (Eu-MOF) probe. Specifically, the Eu-MOF was facilely synthesized via directly mixing Eu³⁺ with 1,10-phenanthroline-2,9-dicarboxylic acid (PDA) ligand at room temperature, which exhibited well-stable red fluorescence at 612 nm. Upon the addition of target LEV, the significant fluorescence quenching from Eu³⁺ was observed owing to the inner filter effect between the Eu-MOF and LEV. While the intrinsic fluorescence for LEV at 462 nm was gradually enhanced, thereby realizing the self-calibration ratiometric fluorescence responses to LEV. Through this strategy, LEV can be detected down to 27 nmol/L. Furthermore, a test paper-based Eu-MOF integrated with the smartphone assisted RGB color analysis was exploited for the quantitative monitoring of LEV through the multi-color changes from red to blue, thus achieved portable, convenient and visual detection of LEV in honey and milk samples. Therefore, the developed strategy could provide a useful tool for supporting the practical on-site test in food samples.
- Target self-calibration,
- Ratiometric fluorescence,
- Europium metal-organic Framework,
- Multi-color visual detection,
- Levofloxacin
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