Citation: Qian Chen, Anyang Shen, Taotao Huang, Xinya Han, Jian Zhang, Hui Jiang, Renyong Liu, Yong Pan, Kui Zhang. Ultrasensitive and selective detection of chemical nerve agent simulants based on naphthalimide functionalized chitosan as fluorescent nanofibers[J]. Chinese Chemical Letters, ;2025, 36(7): 110331. doi: 10.1016/j.cclet.2024.110331 shu

Ultrasensitive and selective detection of chemical nerve agent simulants based on naphthalimide functionalized chitosan as fluorescent nanofibers

Qian Chen ^a ,
Anyang Shen ^a ,
Taotao Huang ^a ,
Xinya Han ^a ,
Jian Zhang ^a ,
Hui Jiang ^b ,
Renyong Liu ^c ,
Yong Pan ^b ,
Kui Zhang ^{a, *,}

a.
School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243032, China
b.
State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China
c.
Key Laboratory of Biomimetic Sensor and Detecting Technology of Anhui Province, School of Materials and Chemical Engineering, West Anhui University, Lu'an 237012, China

zhangkui@mail.ustc.edu.cn

Received Date: 24 March 2024
Revised Date: 8 July 2024
Accepted Date: 9 August 2024
Available Online: 14 August 2024

Figures(7)

The organic fluorescent probes were widely explored for specific detection of chemical nerve agent simulants. However, the fluorescence quenching, long-time response, and limitation of detection further impeded their practical applications. Herein, the fluorescent nanofiber chitosan-1 was prepared through the modification of chitosan with 1,8-naphthalimide as fluorophore and piperazine as the detection segment. The high specific surface of fluorescent nanofiber chitosan-1 showed ultrasensitive and selective detection of diethyl chlorophosphate (DCP) in solution and vapor. The satisfied linear relationship between the fluorescent intensity and the concentration of DCP ranging from 0 µmol/L to 100 µmol/L was obtained. The limitation of detection was measured as low as 2.2 nmol/L within 30 s. The sensing mechanism was explored through the photoinduced electron transfer (PET) mechanism which was confirmed by ¹H, ³¹P NMR, and mass spectra (MS). The ultrasensitive detection of nanofibers may provide valuable insights for enhancing the sensing performance in visually detecting chemical nerve agents.
- Fluorescence detection,
- Nerve agent simulants,
- Visual detection,
- Nanofiber
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