Citation: Ruijianghan Shi, Yujie Zhu, Weitong Lu, Yuhan Shao, Yang Chen, Mi Zhou, Yunfeng Lin, Sirong Shi. Tetrahedral framework nucleic acids enhance osteogenic differentiation and prevent apoptosis for dental follicle stem cell therapy in diabetic bone repair[J]. Chinese Chemical Letters, ;2025, 36(5): 110241. doi: 10.1016/j.cclet.2024.110241 shu

Tetrahedral framework nucleic acids enhance osteogenic differentiation and prevent apoptosis for dental follicle stem cell therapy in diabetic bone repair

Ruijianghan Shi ^{a, b} ,
Yujie Zhu ^{a, b} ,
Weitong Lu ^{a, b} ,
Yuhan Shao ^{a, b} ,
Yang Chen ^c ,
Mi Zhou ^{a, b} ,
Yunfeng Lin ^{a, b} ,
Sirong Shi ^{a, b, *,}

a.
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
b.
Sichuan Provincial Engineering Research Center of Oral Biomaterials, Chengdu 610041, China
c.
Department of Pediatric Surgery, Department of Liver Surgery & Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, China

sirongshi@scu.edu.cn

Received Date: 21 May 2024
Revised Date: 9 July 2024
Accepted Date: 10 July 2024
Available Online: 14 July 2024

Figures(5)

Hyperglycemia resulting from diabetes mellitus (DM) exacerbates osteoporosis and fractures, damaging bone regeneration due to impaired healing capacity. Stem cell therapy offers the potential for bone repair, accelerating the healing of bone defects by introducing stem cells with osteogenic differentiation ability. Dental follicle stem cells (DFSCs) are a newly emerging type of dental stem cells that not only have the potential for multipotent differentiation but also hold easy accessibility and can stand long-term storage. However, DM-associated oxidative stress and inflammation elevate the risk of DFSCs dysfunction and apoptosis, diminishing stem cell therapy efficacy. Recent nanomaterial advances, particularly in DNA nanostructures like tetrahedral framework nucleic acids (tFNAs), have been promising candidates for modulating cellular behaviors. Accumulating experiments have shown that tFNAs' cell proliferation and migration-promoting ability and induce osteogenic differentiation of stem cells. Meanwhile, tFNAs can scavenge reactive oxygen species (ROS) and downregulate the secretion of inflammatory factors by inhibiting various inflammation-related signaling pathways. Here, we applied tFNAs to modify DFSCs and observed enhanced osteogenic differentiation alongside ROS scavenging and anti-inflammatory effects mediated by suppressing the ROS/mitogen-activated protein kinases (MAPKs)/nuclear factor kappa-B (NF-κB) signaling pathway. This intervention reduced stem cell apoptosis, bolstering stem cell therapy efficacy in DM. Our study establishes a simple yet potent tFNAs-DFSCs system, offering potential as a bone repair agent for future DM treatment.
- Tetrahedral framework nucleic acids,
- DNA nanomaterials,
- Diabetes mellitus,
- Dental follicle stem cells,
- ROS/MAPKs/NF-κB pathway
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